Evidence map›Paper›PMID 33817893›Full record

ArticleNMR in biomedicine2021

Imaging acute effects of bevacizumab on tumor vascular kinetics in a preclinical orthotopic model of U251 glioma.

Tavarekere N Nagaraja, Rasha Elmghirbi, Stephen L Brown, Julian A Rey, Lonni Schultz, Abir Mukherjee, Glauber Cabral, Swayamprava Panda, Ian Y Lee, Malisa Sarntinoranont and 3 more

Open access · greenAbstract read
In one paragraph

Article in NMR in biomedicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Current trends in the characterization and monitoring of vascular response to cancer therapy.Cancer imaging : the official publication of the International Cancer Imaging Society · 2024
    Review
  3. Article
  4. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Tavarekere N NagarajaDepartment of Neurosurgery, Henry Ford Hospital, Detroit, Michigan, USA.ORCID 0000-0001-5074-3134
Rasha ElmghirbiDepartment of Neurology, Henry Ford Hospital, Detroit, Michigan, USA.
Stephen L BrownDepartment of Radiation Oncology, Henry Ford Hospital, Detroit, Michigan, USA.
Julian A ReyDepartment of Mechanical and Aerospace Engineering, University of Florida, Gainesville, Florida, USA.
Lonni SchultzDepartment of Neurosurgery, Henry Ford Hospital, Detroit, Michigan, USA.
Abir MukherjeeDepartment of Pathology, Henry Ford Hospital, Detroit, Michigan, USA.
Glauber CabralDepartment of Neurology, Henry Ford Hospital, Detroit, Michigan, USA.
Swayamprava PandaDepartment of Neurology, Henry Ford Hospital, Detroit, Michigan, USA.
Ian Y LeeDepartment of Neurosurgery, Henry Ford Hospital, Detroit, Michigan, USA.
Malisa SarntinoranontDepartment of Mechanical and Aerospace Engineering, University of Florida, Gainesville, Florida, USA.
Kelly A KeenanDepartment of Neurosurgery, Henry Ford Hospital, Detroit, Michigan, USA.
Robert A KnightDepartment of Neurology, Henry Ford Hospital, Detroit, Michigan, USA.
James R EwingDepartment of Neurology, Henry Ford Hospital, Detroit, Michigan, USA.ORCID 0000-0003-0145-0655
Henry Ford Hospital · USOakland University · USUniversity of Florida · US

Funding

MRI Signatures of Response to High-Dose Radiotherapy in Rat Models of Cerebral TumorR01CA218596 · NCI · HENRY FORD HEALTH SYSTEM · PI BROWN, STEPHEN L, EWING, JAMES R · 2018 to 2022
$2.4M
MRI Biomarkers of Response in Cerebral TumorsR01CA135329 · NCI · HENRY FORD HEALTH SYSTEM · PI EWING, JAMES R · 2009 to 2013
$1.5M
NCI NIH HHS R01 CA135329NCI NIH HHS R01 CA218596
6 · The paper itself

Abstract

The effect of a human vascular endothelial growth factor antibody on the vasculature of human tumor grown in rat brain was studied. Using dynamic contrast-enhanced magnetic resonance imaging, the effects of intravenous bevacizumab (Avastin; 10 mg/kg) were examined before and at postadministration times of 1, 2, 4, 8, 12 and 24 h (N = 26; 4-5 per time point) in a rat model of orthotopic, U251 glioblastoma (GBM). The commonly estimated vascular parameters for an MR contrast agent were: (i) plasma distribution volume (v

Indexed as

AnimalsBevacizumabCell Line, TumorFemaleGliomaHumansKineticsMagnetic Resonance ImagingModels, BiologicalRatsTissue DistributionBevacizumabAvastin, DCE-MRI, distribution volume, GBM, Ktrans, Magnevist, peri-tumoral fluid flow, rat, tumor interstitial fluid pressure

Identifiers

PMID33817893
PMCPMC8978145
OpenAlexW3150269918

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.