ArticleJournal of veterinary internal medicine2021
Nebulized dexamethasone sodium phosphate in the treatment of horses with severe asthma.
Article in Journal of veterinary internal medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 12 citations in OpenAlex.
- Inhaled Corticosteroids Influence Pulmonary Microbiota in Severe Equine Asthma.Animals : an open access journal from MDPI · 2026Article
- A randomized, masked, crossover, clinical trial of the efficacy and safety of nebulized albuterol sulfate and dexamethasone sodium phosphate in asthmatic horses.Journal of veterinary internal medicine · 2026Article
- Use of a Capsaicin Cough Challenge Test to Compare Four Different Techniques for Nebulization Delivery in Cats.Veterinary sciences · 2024Article
- A CONSORT-guided, randomized, double-blind, controlled pilot clinical trial of inhaled lidocaine for the treatment of equine asthma.Canadian journal of veterinary research = Revue canadienne de recherche veterinaire · 2022Article
- Clinical effects and pharmacokinetics of nebulized lidocaine in healthy horses.Frontiers in veterinary science · 2022Article
- Nebulized dexamethasone sodium phosphate in the treatment of horses with severe asthma.Journal of veterinary internal medicine · 2021Article
- A CONSORT-guided, randomized controlled clinical trial of nebulized administration of dexamethasone and saline on lower airway cytokine mRNA expression in horses with moderate asthma.Journal of veterinary internal medicineArticle
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
backgroundA study reported low systemic availability of injectable dexamethasone nebulized to healthy horses using the Flexineb mask. When used in horses with severe asthma and a different nebulizer, lack of efficacy and cortisol suppression were observed. HYPOTHESIS: Nebulized dexamethasone is as effective as PO administration for the treatment of severe asthma in horses. ANIMALS: Twelve horses with severe asthma from a research herd.
methodsRandomized clinical trial. Horses were divided into 2 groups and received 5 mg of dexamethasone sodium phosphate by nebulization using a Flexineb mask (NE, n = 6) or PO (OR, n = 6) q24h for 7 days. Lung function and serum cortisol concentrations were evaluated at baseline, after 4 days of treatment (D4) and 1 day after the last treatment (D8). Data were analyzed using linear mixed models with Benjamini-Hochberg adjustments.
resultsLung resistance significantly improved at D4 (mean decrease ± SD, -1.5 ± 0.45 cm H₂O/L/s; 95% confidence interval [CI], -2; -0.6) and D8 (-1.4 ± 0.45 cm H₂O/L/s; 95% CI, -2.4; -0.5) compared to baseline in the OR group only (P = .004 and .01, respectively). Serum cortisol concentration was significantly decreased at D4 and D8 for both groups (maximum decrease, -1.2 ± 0.3 μg/dL; 95% CI, -1.9; -0.6 at D4 for NE group and -2.2 ± 0.3 μg/dL; 95% CI, -2.8; -1.6 at D8 for OR group; P < .001). CONCLUSIONS AND CLINICAL IMPORTANCE: Oral, but not nebulized dexamethasone is an effective therapy for horses with severe asthma and both treatment modalities inhibit the hypothalamic-pituitary-adrenal axis.
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