SynthesisMovement disorders : official journal of the Movement Disorder Society2021
Neuroticism and Risk of Parkinson's Disease: A Meta-Analysis.
Synthesis in Movement disorders : official journal of the Movement Disorder Society, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 3 of them syntheses that pooled it.
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Who cites it
29 citing papers in PubMed, 3 syntheses or guidelines pooled it, 36 citations in OpenAlex.
- Prediabetes and the incidence of Parkinson's disease: A meta-analysis.Biomolecules & biomedicine · 2024Pooled it
- Systematic reviews of the acute effects of amphetamine on working memory and other cognitive performances in healthy individuals, with a focus on the potential influence of personality traits.Human psychopharmacology · 2023Pooled it
- Five-factor model personality traits and grip strength: Meta-analysis of seven studies.Journal of psychosomatic research · 2022Pooled it
- Clinical, cognitive and neuropsychiatric correlates of personality in Wilson's disease.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026Article
- Association between neuroticism and cosmetic mammoplasty: Results from a bidirectional Mendelian randomization study.Medicine · 2026Article
- Fatigue: a common but poorly understood symptom in neurological and non-neurological diseases.Nature reviews. Neurology · 2025Review
- Neuropsychological insights into creativity in people with Parkinson's disease.NPJ Parkinson's disease · 2025Article
- The mediating role of biological age in the impact of mood instability symptoms on neurodegenerative disease and mortality.BMC medicine · 2025Article
- Personality and falls: evidence from three samples.The journals of gerontology. Series B, Psychological sciences and social sciences · 2025Article
- Neuroticism is associated with future disease and mortality risks.Chinese medical journal · 2025Article
- Large-scale exome sequencing identified 18 novel genes for neuroticism in 394,005 UK-based individuals.Nature human behaviour · 2025Article
- The 7 Muses of Neuro-Creative Cycle: How some patients with Parkinson's disease can unleash latent creativity.AIMS neuroscience · 2025Article
- Association of worrier trait with the risk of Parkinson's disease: a longitudinal study based on 457,180 UK Biobank participants.Frontiers in psychology · 2025Article
- Neuroticism, loneliness, all-cause and cause-specific mortality: A 17-year study of nearly 500,000 individuals.Journal of affective disorders · 2025Article
- Biological aging analysis based on DNA methylation status for social anxiety disorder.Neuropsychopharmacology reports · 2024Article
- Deep learning predicts prevalent and incident Parkinson's disease from UK Biobank fundus imaging.Scientific reports · 2024Article
- Meaning in life and Parkinson's disease in the UK Biobank.Clinical parkinsonism & related disorders · 2024Article
- Association Between Optimism and Incident Stroke Among Stroke Survivors: Findings From the English Longitudinal Study of Ageing.Annals of behavioral medicine : a publication of the Society of Behavioral Medicine · 2024Article
- Neuroticism and white matter hyperintensities.Journal of psychiatric research · 2023Article
- The association between personality and plasma biomarkers of astrogliosis and neuronal injury.Neurobiology of aging · 2023Article
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Authors and funding
7 authors at 5 institutions in 4 countries.
Funding
Abstract
backgroundNeuroticism is linked to mood disorders and Alzheimer's disease, but fewer studies have tested the prospective association with Parkinson's disease (PD).
objectivesTo examine the association between neuroticism and risk of PD in a large cohort and a meta-analysis of prospective cohort studies.
methodsParticipants from the UK Biobank (N = 490,755) completed a neuroticism scale in 2006-2010. Incident PD was ascertained using electronic health records or death records up to 2018. The systematic search and meta-analysis followed the MOOSE guidelines.
resultsDuring 11.91 years of follow-up (mean = 8.88 years; 4,360,105 person-years) 1142 incident PD cases were identified. Neuroticism was associated with higher risk of incident PD, both as continuous (HR = 1.28; 95% CI: 1.21-1.36) and categorical variable (top vs. bottom quartiles: HR = 1.88; 95% CI: 1.60-2.22). The association remained significant after accounting for age, sex, smoking, physical activity, anxiety, and depressed mood, and after excluding cases that occurred within the first 5 years of follow-up. The associations were similar for women and men and across levels of socioeconomic status. Random-effect meta-analysis of four prospective studies (N = 548,284) found neuroticism associated with increased risk of incident PD (HR = 1.82; 95% CI: 1.59-2.08; P = 7.31
conclusionThe results from the large UK Biobank and meta-analysis of prospective studies indicate that neuroticism is consistently associated with a higher risk of incident PD. © 2021 International Parkinson and Movement Disorder Society.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.