ArticleAging clinical and experimental research2021
Impact of thrombus aspiration in frail STEMI patients.
Article in Aging clinical and experimental research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 7 citations in OpenAlex.
- Addition of eptifibatide and manual thrombus aspiration to ticagrelor does not improve long-term survival after STEMI treated with primary PCI.Frontiers in pharmacology · 2024Article
- Outcomes of early versus delayed invasive strategy in older adults with non-ST-segment elevation myocardial infarction.Scientific reports · 2022Article
- Diabetes and restenosis.Cardiovascular diabetology · 2022Review
- Validation of plasma D-dimer in Chinese patients with acute non-ST segment elevation myocardial infarction.Frontiers in cardiovascular medicine · 2022Article
- Article
- Clinical Impact of Thrombus Aspiration and Interaction With D-Dimer Levels in Patients With ST-Segment Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention.Frontiers in cardiovascular medicine · 2021Article
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Authors and funding
7 authors at 5 institutions in 2 countries.
Funding
Abstract
backgroundDespite primary percutaneous coronary intervention (PPCI) is generally considered the best therapy in older frail adults with ST-segment elevation myocardial infarction (STEMI), the incidence of re-hospitalization for cardiovascular diseases remains significant in these patients.
aimsWe hypothesized that thrombus aspiration (TA) before PPCI could be a useful treatment for reducing mortality and rehospitalizations in frail patients undergoing PPCI for STEMI.
methodsWe conducted a study comparing PPCI alone vs TA + PPCI in frail STEMI patients. We examined a cohort of consecutive frail patients aged ≥ 65 years with first STEMI treated with PPCI between February 2008 and July 2015 at the Department of Cardiology of the "Cardarelli" Hospital in Naples, Italy.
resultsThe study was completed by 389 patients (PPCI: 195, TA + PPCI: 194). At 1-month follow-up, the rate of death from any cause was 7.0% in patients treated with PPCI alone vs 3.0% in patients treated with TA + PPCI (p 0.036), whereas death from cardiovascular causes was 6.0% in the PPCI group vs 3.0% in the TA + PPCI group (p 0.028). Equally important, the rate of re-hospitalization due to heart failure was 7.5% in the PPCI group vs 4.0% in TA + PPCI group (p 0.025) and the rate of re-hospitalization due to acute coronary syndrome was 10.0% in the PPCI group vs 4.5% in the TA + PPCI group (p 0.016).
conclusionThese results indicate the importance of TA in the treatment of STEMI in a group of high-risk patients such as elderly with frailty.
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