Evidence map›Paper›PMID 33817764›Full record

ArticleVirchows Archiv : an international journal of pathology2021

Comprehensive genomic profiling and prognostic analysis of cervical gastric-type mucinous adenocarcinoma.

Shanshan Lu, Junping Shi, Xiaobo Zhang, Fangzhou Kong, Lili Liu, Xiaowei Dong, Kai Wang, Danhua Shen

Abstract read
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In one paragraph

Article in Virchows Archiv : an international journal of pathology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
3.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 34 citations in OpenAlex.

  1. Article
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  5. Review
  6. Article
  7. HPV-Independent Cervical Cancer-A New Challenge of Modern Oncology.International journal of molecular sciences · 2025
    Review
  8. Article
  9. Article
  10. Molecular Features of HPV-Independent Cervical Cancers.Pathogens (Basel, Switzerland) · 2025
    Review
  11. Article
  12. Article
  13. Review
  14. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Shanshan LuDepartment of Pathology, Peking University People's Hospital, No. 11 Xizhimen South Street, Xicheng District, Beijing, 100044, China.
Junping ShiOrigiMed, No. 115 Xinjunhuan Road, 5th Floor, Building 3, Shanghai, 201114, China.
Xiaobo ZhangDepartment of Pathology, Peking University People's Hospital, No. 11 Xizhimen South Street, Xicheng District, Beijing, 100044, China.
Fangzhou KongDepartment of Pathology, Peking University People's Hospital, No. 11 Xizhimen South Street, Xicheng District, Beijing, 100044, China.
Lili LiuDepartment of Pathology, Peking University People's Hospital, No. 11 Xizhimen South Street, Xicheng District, Beijing, 100044, China.
Xiaowei DongOrigiMed, No. 115 Xinjunhuan Road, 5th Floor, Building 3, Shanghai, 201114, China.
Kai WangOrigiMed, No. 115 Xinjunhuan Road, 5th Floor, Building 3, Shanghai, 201114, China.
Danhua ShenDepartment of Pathology, Peking University People's Hospital, No. 11 Xizhimen South Street, Xicheng District, Beijing, 100044, China. Shenpath59@163.com.
Peking University · CNUnimed Medical Institute · CNPeking University People's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gastric-type mucinous adenocarcinoma (GAS) is an uncommon cervical adenocarcinoma, which is not associated with human papillomavirus (HPV) infection. Compared with HPV-associated cervical adenocarcinoma, GAS has characteristics of larger volume, deep invasion, and easy to metastasize to distant sites. Also, GAS is typically resistant to chemo/radiotherapy. Few studies have reported the molecular genetic characteristics of GAS. In order to investigate the molecular genetic characteristics of GAS and reveal its possible pathogenesis, 15 GAS patients were enrolled from Peking University People's Hospital (2009-2019) and examined with next-generation sequencing (NGS). Based on the clinicopathologic feature analysis, we found that the presence of lymph node metastasis and extensive lymphovascular invasion were associated with poor survival outcomes of GAS (p = 0.0042 and p = 0.005, respectively). Based on the NGS testing, our results showed that the most frequently mutated gene was TP53 (8/15, 53.3%), followed by STK11, CDKN2A, and ARID1A. STK11 mutations were more frequent in well-differentiated GAS (33.3% vs. 0.0%, p = 0.026) and patients with extensive lymphovascular invasion (33.3% vs. 0.0%, p = 0.044). Survival analysis revealed that STK11 mutations were significantly associated with the poor prognosis of GAS (p = 0.01). Our results also showed that mutations in the target drug were detected in 53.3% of GAS patients. Patients with ERBB2 amplification (13.3%) presented the highest level of evidence according to OncoKB recommendations. These results indicate that the genomic alterations of GAS mainly involved the cell cycle and PI3K/AKT signaling pathways, and some therapeutic candidates were identified in GAS patients.

Indexed as

Gene Expression ProfilingTranscriptomeAdenocarcinoma, MucinousAdultAgedBiomarkers, TumorFemaleGene AmplificationGenetic Predisposition to DiseaseHigh-Throughput Nucleotide SequencingHumansLymphatic MetastasisMiddle AgedMutationNeoplasm InvasivenessPhenotypeBiomarkers, TumorCervixGastric-type mucinous adenocarcinomaGenomic alterationsMolecular targetsNext-generation sequencingPrognosis

Identifiers

PMID33817764
OpenAlexW3141166704

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.