ArticleRomanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie
Involvement of inflammatory cells in chronic rhinosinusitis with nasal polyps.
Article in Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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5 citing papers in PubMed, 3 citations in OpenAlex.
- Surgical, Dermatological and Morphopathological Considerations in the Diagnosis and Treatment of Cutaneous Lymphoproliferative Tumors, Primary CD4.Medicina (Kaunas, Lithuania) · 2022Article
- Current approach of juvenile nasopharyngeal angiofibroma: a case series.Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologieArticle
- Histopathological parameters and immunoexpression of CD45RO (CLA) and CD68 in chronic rhinosinusitis with nasal polyps.Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologieArticle
- TLR4 expression and its immunopathogenic role in inflammatory radicular cysts: a clinicopathological study.Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologieArticle
- Vascular remodeling and microvessel density in inflammatory radicular cysts: a CD34 immunohistochemical analysis.Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologieArticle
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9 authors at 1 institution in 1 country.
Funding
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Abstract
Inflammation plays an important role in the pathogenesis of nasal polyps. Understanding the biomolecular action mechanisms of inflammatory elements can contribute to improving the prognosis of these lesions. The study analyzed the distribution and immunohistochemically quantified eosinophils [eosinophil major basic protein (BMK-13)], lymphocytes [cluster of differentiation (CD) 4, CD8, CD20] and plasmocytes (CD138) in both the epithelial and stromal compartment in relation to composite scores, which included specific histopathological parameters for 50 sinonasal polyps. Inflammatory elements predominated at stromal level, the high histological composite scores being frequently associated with increased expression of inflammatory elements. Also, the numerical distribution of inflammatory elements indicated positive linear relations within the groups BMK-13∕CD8 and CD4∕CD20∕CD138, and a negative linear relation between the two groups. This aspect can support the existence of alternative or sequential pathogenic mechanisms involved in the pathogenesis of sinonasal polyps, and the results obtained can be used for a better stratification of patients in order to optimize the therapy.
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