ReviewBioactive materials2021
The recent advances in scaffolds for integrated periodontal regeneration.
Review in Bioactive materials, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 78 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
78 citing papers in PubMed, 1 synthesis or guideline pooled it, 147 citations in OpenAlex.
- Appraising and comparing the role of autogenous periosteal graft as a barrier membrane in the treatment of intrabony defects in chronic periodontitis cases: A systematic review and meta-analysis.International journal of medical sciences · 2024Pooled it
- Clinical, radiographic and molecular efficacy of LLLT along with minimally invasive flaps in regeneration of periodontal intrabony defects: a randomized controlled clinical trial.Clinical oral investigations · 2025Trial
- Evolution of scaffold materials for periodontal therapeutics over two decades (2005-2025): A bibliometric mapping analysis.The Saudi dental journal · 2026Review
- Review
- Local periodontal injection, systemic heart repair: A dual-functional hydrogel for non-invasive concurrent treatment of periodontitis and myocardial infarction.Bioactive materials · 2026Article
- 3D-Bioprinted Multifunctional Nanocomposite Scaffolds for Alveolar Bone-Periodontal Ligament-Root Cementum Regeneration: A Narrative Review.Biomimetics (Basel, Switzerland) · 2026Review
- Scaffold-Based Biomaterials for Periodontal Regeneration in Periodontitis: A Systematic Review and Meta-Analysis.Journal of functional biomaterials · 2026Review
- Intelligent multimodal-energy-driven piezoelectric antibacterial platforms: From structural control to system-level diagnosis.Materials today. Bio · 2026Review
- Fuel to fire: developmental niche-empowered ApoEVs unlock adult hierarchical tissue regenerative potential via mitochondrial complex I-driven developmental metabolic profile.International journal of oral science · 2026Article
- Bioengineered extracellular vesicles escape lysosomal degradation and deliver Tet-PKM2 for macrophage immunometabolic reprogramming and periodontitis treatment.Bioactive materials · 2026Article
- Microenvironment-mediated stem cell fate in periodontal tissue remodeling and repair.Bioactive materials · 2026Review
- Stem cell-driven biomedical technologies for tooth regeneration: engineering scaffolds, organoid models, and molecular targeted strategies.Stem cell research & therapy · 2026Review
- Visualization Analysis and Knowledge Structure Evolution of Hydrogel Applications in Dentistry.International dental journal · 2026Article
- Combined Piezoelectric and Laser Therapy for Severely Compromised Teeth: Two Case Reports.Case reports in dentistry · 2026Article
- A degradable hydrogel scaffold incorporating the LL-37 for gingival soft tissue regeneration.Regenerative biomaterials · 2026Article
- Coaxial electrospinning of poly(ɛ-caprolactone)/gelatin core-shell biodegradable implants for localized delivery of metronidazole and dexamethasone for periodontal applications.Frontiers in bioengineering and biotechnology · 2026Article
- Enamel Matrix Derivative in Dental Pulp Regeneration: Biological Basis, Mechanistic Insights, and Translational Considerations.Stem cells international · 2026Review
- Harnessing Oxidized Alginate Microgels for Rapid and Self-Assembling Dental Tissue Organogenesis In Vitro and In Vivo.Small science · 2025Article
- Evaluating the Clinical Efficacy of Membrane-Assisted Regenerative Therapy in Peri-Implantitis Management: A Comprehensive Review Incorporating Systematic Review Evidence.Materials (Basel, Switzerland) · 2025Review
- Challenges of Ozone Therapy in Periodontal Regeneration: A Narrative Review and Possible Therapeutic Improvements.Current issues in molecular biology · 2025Review
18 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The periodontium is an integrated, functional unit of multiple tissues surrounding and supporting the tooth, including but not limited to cementum (CM), periodontal ligament (PDL) and alveolar bone (AB). Periodontal tissues can be destructed by chronic periodontal disease, which can lead to tooth loss. In support of the treatment for periodontally diseased tooth, various biomaterials have been applied starting as a contact inhibition membrane in the guided tissue regeneration (GTR) that is the current gold standard in dental clinic. Recently, various biomaterials have been prepared in a form of tissue engineering scaffold to facilitate the regeneration of damaged periodontal tissues. From a physical substrate to support healing of a single type of periodontal tissue to multi-phase/bioactive scaffold system to guide an integrated regeneration of periodontium, technologies for scaffold fabrication have emerged in last years. This review covers the recent advancements in development of scaffolds designed for periodontal tissue regeneration and their efficacy tested
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.