Evidence map›Paper›PMID 33817407›Full record

ArticleNutrition and healthy aging2019

Aging research using the common marmoset: Focus on aging interventions.

Corinna N Ross, Adam B Salmon

Open access · diamondAbstract read
In one paragraph

Article in Nutrition and healthy aging, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 38 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Corinna N RossDepartment of Science and Mathematics, Texas A&M University San Antonio, San Antonio, TX, USA.
Adam B SalmonThe Sam and Ann Barshop Institute for Longevity and Aging Studies and The University of Texas Health Science Center at San Antonio, San Antonio TX, USA.
Texas A&M University – San Antonio · USThe University of Texas Health Science Center at San Antonio · US

Funding

TRANSGENIC COREP30AG013319 · NIA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI JAMES FLOYD NELSON · 1995 to 2026
$30.6M
San Antonio OAIC - Research Education Component (REC)P30AG044271 · NIA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Adam Salmon, Elena Volpi · 2015 to 2026
$14.1M
The role of mTOR inhibition on longevity and healthy aging in a non-human primateR01AG050797 · NIA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI SALMON, ADAM · 2015 to 2019
$2.7M
Primary fibroblast resiliency as a predictor of health and lifespan in miceR01AG057431 · NIA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI SALMON, ADAM · 2017 to 2021
$1.6M
NIA NIH HHS P30 AG013319NIA NIH HHS P30 AG044271NIA NIH HHS R01 AG050797NIA NIH HHS R01 AG057431
6 · The paper itself

Abstract

Traditional animal models have been used to make seminal discoveries in biomedical research including a better understanding of the biology of the aging process. However, translation of these findings from laboratory to clinical populations has likely been hindered due to fundamental biological and physiological differences between common laboratory animals and humans. Non-human primates (NHP) may serve as an effective bridge towards translation, and short-lived NHP like the common marmoset offer many advantages as models for aging research. Here, we address these advantages and discuss what is currently understood about the changes in physiology and pathology that occur with age in the marmoset. In addition, we discuss how aging research might best utilize this model resource, and outline an ongoing study to address whether pharmaceutical intervention can slow aging in the marmoset. With this manuscript, we clarify how common marmosets might assist researchers in geroscience as a potential model for pre-clinical translation.

Indexed as

longevityMarmosetmTORnon-human primaterapamycinresilience

Identifiers

PMID33817407
PMCPMC8018684
OpenAlexW2884699563

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.