Evidence map›Paper›PMID 33817339›Full record

ArticleEuropean stroke journal2021

Rates, risks and routes to reduce vascular dementia (R4vad), a UK-wide multicentre prospective observational cohort study of cognition after stroke: Protocol.

Joanna M Wardlaw, Fergus Doubal, Rosalind Brown, Ellen Backhouse, Lisa Woodhouse, Philip Bath, Terence J Quinn, Thompson Robinson, Hugh S Markus, Richard McManus and 9 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European stroke journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 4 pooled it
2.0field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 4 syntheses or guidelines pooled it, 28 citations in OpenAlex.

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  3. The effects of exercise intervention on cognition and motor function in stroke survivors: a systematic review and meta-analysis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 10 institutions in 3 countries.

Joanna M WardlawCentre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.ORCID https://orcid.org/0000-0002-9812-6642
Fergus DoubalCentre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.
Rosalind BrownCentre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.
Ellen BackhouseCentre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.
Lisa WoodhouseStroke Trials Unit, Division of Clinical Neuroscience, University of Nottingham, Nottingham, UK.
Philip BathStroke Trials Unit, Division of Clinical Neuroscience, University of Nottingham, Nottingham, UK.
Terence J QuinnInstitute of Cardiovascular and Medical Sciences, University of Glasgow, UK.
Thompson RobinsonDepartment of Cardiovascular Sciences and NIHR Leicester Biomedical Research Centre, University of Leicester, UK.
Hugh S MarkusDepartment of Neurology, University of Cambridge, Cambridge, UK.
Richard McManusDepartment of General Practice, University of Oxford, UK.
John T O'BrienDepartment of Psychiatry, University of Cambridge, Cambridge, UK.
David J WerringNational Hospital for Neurology and Neurosurgery, London, UK.
Nikola SpriggStroke Trials Unit, Division of Clinical Neuroscience, University of Nottingham, Nottingham, UK.
Adrian Parry-JonesDivision of Cardiovascular Sciences, School of Medicine, Faculty of Biology, Medicine & Health, Manchester Academic Health Science Centre, The University of Manchester, Manchester, UK.
Rhian M TouyzInstitute of Cardiovascular and Medical Sciences, University of Glasgow, UK.
Steven WilliamsKing's College Hospital NHS Foundation Trust, School of Biomedical Engineering and Imaging Sciences, King's College London, UK.
Yee-Haur MahKing's College Hospital NHS Foundation Trust, School of Biomedical Engineering and Imaging Sciences, King's College London, UK.
Hedley EmsleyDepartment of Neurology, Lancashire Teaching Hospitals NHS Foundation Trust & Lancaster Medical School, Lancaster University, UK.
R4VaD Investigators
MRC Centre for Regenerative Medicine · GBUniversity of Nottingham · GBKing's College London · GBUniversity of Cambridge · GBUniversity of Glasgow · GBLancashire Teaching Hospitals NHS Foundation Trust · GBManchester Academic Health Science Centre · GBUniversity College Hospital · GBUniversity of Leicester · GBUniversity of Oxford · GB

Funding

British Heart Foundation CH/12/4/29762
6 · The paper itself

Abstract

backgroundStroke commonly affects cognition and, by definition, much vascular dementia follows stroke. However, there are fundamental limitations in our understanding of vascular cognitive impairment, restricting understanding of prevalence, trajectories, mechanisms, prevention, treatment and patient-service needs.

aimsRates, Risks and Routes to Reduce Vascular Dementia (R4VaD) is an observational cohort study of post-stroke cognition. We aim to recruit a wide range of patients with stroke, presenting to geographically diverse UK hospitals, into a longitudinal study to determine rates of, and risk factors for, cognitive and related impairments after stroke, to assess potential mechanisms and improve prediction models.

methodsWe will recruit at least 2000 patients within six weeks of stroke with or without capacity to consent and collect baseline demographic, clinical, socioeconomic, lifestyle, cognitive, neuropsychiatric and informant data using streamlined patient-centred methods appropriate to the stage after stroke. We will obtain more detailed assessments at four to eight weeks after the baseline assessment and follow-up by phone and post yearly to at least two years. We will assess diagnostic neuroimaging in all and high-sensitivity inflammatory markers, genetics, blood pressure and diffusion tensor imaging in mechanistic sub-studies.

Indexed as

cognitiondementiaobservationalStroke

Identifiers

PMID33817339
PMCPMC7995325
OpenAlexW3089635599

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.