Evidence map›Paper›PMID 33817199›Full record

ArticleOpen life sciences2019

Protective Effects of Emodin on Lung Injuries in Rat Models of Liver Fibrosis.

Lili Zhang, Huiying Zhang, Limin Wang, Yimin Fan, Cuiying Zhang, Xujiong Li, Dewu Han, Cheng Ji

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Open life sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 79% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Lili ZhangDepartment of Pathophysiology, Changzhi Medical College, No. 161, Jiefang East Street, Changzhi, Shanxi 046000, China.
Huiying ZhangDepartment of Pathophysiology, Changzhi Medical College, No. 161, Jiefang East Street, Changzhi, Shanxi 046000, China.
Limin WangFunction Laboratory, Changzhi Medical College, Changzhi, Shanxi 046000, China.
Yimin FanFunction Laboratory, Changzhi Medical College, Changzhi, Shanxi 046000, China.
Cuiying ZhangDepartment of Pathophysiology, Changzhi Medical College, No. 161, Jiefang East Street, Changzhi, Shanxi 046000, China.
Xujiong LiDepartment of Pathophysiology, Changzhi Medical College, No. 161, Jiefang East Street, Changzhi, Shanxi 046000, China.
Dewu HanInstitute of Liver Diseases, Shanxi Medical University, Taiyuan, Shanxi 030001, China.
Cheng JiResearch Center for Liver Diseases, Keck School of Medicine, University of Southern California, Loa Angeles, CA 90089, USA.
Changzhi Medical College · CNShanxi Medical University · CNUniversity of Southern California · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe aim of this study is to investigate the protective effects of emodin (EMD) on the lung injuries in the rat models of liver fibrosis.

methodsLiver fibrosis was established in rats and the effect of intervention using EMD treatment was determined. Liver and lung weight coefficients were measured and lung content of TNF-α (tumor necrosis factor α), MDA (malondialdehyde), NO (nitric oxide), and ONOO- (peroxynitrite) were determined. Finally, histopathological changes were evaluated.

resultsCompared with the normal control group, the lung weight coefficient was significantly increased in the fibrosis model group. Moreover, pulmonary edema and inflammatory responses were observed. Levels of TNF-α, MDA, NO, and ONOO- in the lung homogenate were significantly increased in the fibrosis model group. After EMD treatment, the lung weight coefficients were significantly reduced. Moreover, pathological changes in the lung tissue were dramatically alleviated. Levels of TNF-α, MDA, NO, and ONOO- were significantly decreased.

conclusionEMD exhibits protective effects against lung injuries in a rat model of liver fibrosis.

Indexed as

Emodin (EMD)Hepatopulmonary syndrome (HPS)Liver fibrosisLung injuries

Identifiers

PMID33817199
PMCPMC7874798
OpenAlexW3003029455

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.