Evidence map›Paper›PMID 33817198›Full record

ArticleOpen life sciences2019

Neural Remodeling of the Left Atrium in Rats by Rosuvastatin Following Acute Myocardial Infarction.

Jiang-Rong Wang, Meng-Zan Wang, Shao-Hua Zheng, Zhi-Yuan Li

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Open life sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.1field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Jiang-Rong WangDepartment of Cardiology, The First Affiliated Hospital of Shandong First Medical University, Jinan, Shandong 250014, China.
Meng-Zan WangDepartment of Cardiology, People's Hospital of Liaocheng, Liaocheng, Shandong 252000, China.
Shao-Hua ZhengDepartment of Cardiology, People's Hospital of Dongying, Dongying, Shandong 25700, China.
Zhi-Yuan LiDepartment of Cardiology, The First Affiliated Hospital of Shandong First Medical University, Jinan, Shandong 250014, China.
Shandong First Medical University · CNLiaocheng People's Hospital · CNWenzhou Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThis study aims to investigate the effect of rosuvastatin on sympathetic neural remodeling of the left atrium (LA) in rats after myocardial infarction (MI).

methodsRats were randomly divided into a three groups: sham group, statin group, and MI group. The mRNA expression levels of the growth-associated protein-43 (GAP43) and nerve growth factor (NGF) were measured by RT-PCR. Immunohistochemistry was used to detect the distribution and density of GAP43- and NGF-positive nerves. The expression levels of these proteins were quantified by Western blot.

resultsCompared with the sham group, the average optical density (AOD) values of GAP43 and nerve growth factor (NGF)-positive substances in the LA in the statin and MI groups were significantly higher (

conclusionRosuvastatin could effectively improve the sympathetic neural remodeling of LA in MI rats.

Indexed as

arrhythmiaatrial remodelingmyocardial infarctionneural remodelingrosuvastatin

Identifiers

PMID33817198
PMCPMC7874788
OpenAlexW3000139103

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.