Evidence map›Paper›PMID 33817161›Full record

ArticleOpen life sciences2019

Predictive Significance of Serum MMP-9 in Papillary Thyroid Carcinoma.

Dahai Xu, Chang Su, Liang Guo, He Yan, Shaokun Wang, Congwang Yuan, Guohui Chen, Li Pang, Nan Zhang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Open life sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

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  4. Bioinformatic analysis of theFrontiers in cell and developmental biology · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Dahai XuDepartment of Emergency, The First Hospital of Jilin University, 71 Xinmin Street, Changchun, Jilin, 130021,China.
Chang SuDepartment of Thyroid Surgery, the First Hospital of Jilin University, Changchun, Jilin, 130021, China.
Liang GuoDepartment of Pathology, the First Hospital of Jilin University, Changchun, Jilin, 130021, China.
He YanDepartment of Emergency, The First Hospital of Jilin University, 71 Xinmin Street, Changchun, Jilin, 130021,China.
Shaokun WangDepartment of Emergency, The First Hospital of Jilin University, 71 Xinmin Street, Changchun, Jilin, 130021,China.
Congwang YuanDepartment of Pain, Yancheng First People's Hospital, Yancheng, Jiangsu, 224000, China.
Guohui ChenDepartment of Pathology, Jilin City People's Hospital, Jilin, 132000, China.
Li PangDepartment of Emergency, The First Hospital of Jilin University, 71 Xinmin Street, Changchun, Jilin, 130021,China.
Nan ZhangDepartment of Emergency, The First Hospital of Jilin University, 71 Xinmin Street, Changchun, Jilin, 130021,China.
Jilin University · CNFirst Hospital of Jilin University · CNNantong University · CNPeople 's Hospital of Jilin Province · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe incidence of papillary thyroid carcinoma (PTC) is increasing, and there are no reliable serum biomarkers for the diagnosis and prognosis of PTC. This study aimed to assess whether serum matrix metalloproteinase-9 (MMP-9) could serve as an auxiliary diagnostic/prognostic marker for PTC after total and partial thyroidectomy. MATERIAL AND

methodsPostoperative serum MMP-9 concentrations were measured in 182 male patients with PTC, 86 male patients with benign thyroid nodule (BTN), and 62 male healthy controls (HCs). Multivariate logistic regression and Cox regression were applied to evaluate the correlation between variables. The performance of serum MMP-9 in diagnosing PTC and predicting structural persistent/recurrent disease (SPRD) during 48 months of follow-up after initial surgery was evaluated by receiving operating characteristic curve analysis.

resultsThe median serum MMP-9 concentration in the PTC group (79.45 ng/ml) was significantly higher than those in the BTN group (47.35 ng/ml) and HC group (47.71 ng/ml). The area under the curve (AUC) for predicting PTC from BTN was 0.852 at a cut-off value of 60.59 ng/ml. Serum MMP-9 was negatively correlated with disease-free survival (OR 1.026, P=0.001). Serum MMP-9 exhibited good performance in predicting SPRD at a cutoff value of 99.25 ng/ml with an AUC of 0.818. Advanced TNM stage (OR 31.371, P=0.019) and serum MMP-9 ≥99.25 ng/ml (OR 4.103, P=0.022) were independent risk factors for SPRD.

conclusionsSerum MMP-9 potentially represents a good predictive biomarker for PTC diagnosis and prognosis after thyroidectomy in Chinese male patients for whom radio-imaging indicates suspected PTC.

Indexed as

disease-free survivalmatrix metalloproteinase-9papillary thyroid carcinomastructural persistent/recurrent disease

Identifiers

PMID33817161
PMCPMC7874766
OpenAlexW2960471082

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.