ArticleAlzheimer's & dementia (Amsterdam, Netherlands)2021
Selective hippocampal subfield volume reductions in World Trade Center responders with cognitive impairment.
Article in Alzheimer's & dementia (Amsterdam, Netherlands), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Toward multimodal MRI biomarkers of PTSD: functional and structural connectivity signatures in WTC responders.medRxiv : the preprint server for health sciences · 2026Article
- MRI signature of brain age underlying post-traumatic stress disorder in World Trade Center responders.Translational psychiatry · 2025Article
- Increased Aβ40 in plasma is associated with severity of exposure to airborne pollutants at the World Trade Center: a cross-sectional study of neurological biomarkers.The journals of gerontology. Series A, Biological sciences and medical sciences · 2025Article
- Exposure duration and cerebral amyloidosis in the olfactory cortex of World Trade Center responders: A positron emission tomography and magnetic resonance imaging study.Journal of Alzheimer's disease : JAD · 2025Article
- Graph theory-based analysis reveals neural anatomical network alterations in chronic post-traumatic stress disorder.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Functional changes in neural mechanisms underlying post-traumatic stress disorder in World Trade Center responders.Translational psychiatry · 2023Article
- World Trade Center Site Exposure Duration Is Associated with Hippocampal and Cerebral White Matter Neuroinflammation.Molecular neurobiology · 2023Article
- Physical Functional Impairment and the Risk of Incident Mild Cognitive Impairment in an Observational Study of World Trade Center Responders.Neurology. Clinical practice · 2022Article
- Reduced cerebellar cortical thickness in World Trade Center responders with cognitive impairment.Translational psychiatry · 2022Article
- Cognitive impairment and World Trade Centre-related exposures.Nature reviews. Neurology · 2022Review
- Cognitive impact of exposure to airborne particles captured by brain imaging.Advances in neurotoxicology · 2022Article
- DTI Connectometry Analysis Reveals White Matter Changes in Cognitively Impaired World Trade Center Responders at Midlife.Journal of Alzheimer's disease : JAD · 2022Article
- Neuroinflammation in World Trade Center responders at midlife: A pilot study using [Brain, behavior, & immunity - health · 2021Article
- A cortical thinning signature to identify World Trade Center responders with possible dementia.Intelligence-based medicine · 2021Article
- Selective hippocampal subfield volume reductions in World Trade Center responders with cognitive impairment.Alzheimer's & dementia (Amsterdam, Netherlands) · 2021Article
- Plasma amyloid beta 40/42, phosphorylated tau 181, and neurofilament light are associated with cognitive impairment and neuropathological changes among World Trade Center responders: A prospective cohort study of exposures and cognitive aging at midlife.Alzheimer's & dementia (Amsterdam, Netherlands)Article
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Authors and funding
14 authors.
Funding
Abstract
introductionThe objective of this study was to investigate associations between dementia in World Trade Center (WTC) responders and in vivo volumetric measures of hippocampal subfield volumes in WTC responders at midlife.
methodsA sample of 99 WTC responders was divided into dementia and unimpaired groups. Participants underwent structural T1-weighted magnetic resonance imaging. Volumetric measures included the overall hippocampus and eight subfields. Regression models examined volumetric measure of interest adjusting for confounders including intracranial volume.
resultsDementia was associated with smaller hippocampal volume and with reductions across hippocampal subfields. Smaller hippocampal subfield volumes were associated with longer cumulative time worked at the WTC. Domain-specific cognitive performance was associated with lower volumetric measures across hippocampal subregions.
conclusionsThis is the first study to investigate hippocampal subfield volumes in a sample of WTC responders at midlife. Selective hippocampal subfield volume reductions suggested abnormal cognition that were associated with WTC exposure duration.
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