ArticleNeurobiology of stress2021
Genetic evidence for a large overlap and potential bidirectional causal effects between resilience and well-being.
Article in Neurobiology of stress, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Loneliness and depression: bidirectional mendelian randomization analyses using data from three large genome-wide association studies.Molecular psychiatry · 2023Pooled it
- Strengths-based resilience: the biopsychosocial factors that differentiate 12-year mental well-being trajectories following adverse childhood experiences.Psychological medicine · 2026Article
- Using genomic structural equation modeling to examine the genetic architecture of PTSD and life satisfaction phenotypes.European journal of psychotraumatology · 2025Article
- Digital Health Interventions for Military Members, Veterans, and Public Safety Personnel: Scoping Review.JMIR mHealth and uHealth · 2025Article
- Association of Psychological Resilience With Decelerated Brain Aging in Cognitively Healthy World Trade Center Responders.Biological psychiatry global open science · 2025Article
- Digital Health Resilience and Well-Being Interventions for Military Members, Veterans, and Public Safety Personnel: Environmental Scan and Quality Review.JMIR mHealth and uHealth · 2025Review
- *Co-Occurrence and Causality Among ADHD, Dyslexia, and Dyscalculia.Psychological science · 2025Article
- Resilience to Stress and Adversity: A Narrative Review of the Role of Positive Affect.Psychology research and behavior management · 2024Review
- Stress system concordance as a predictor of longitudinal patterns of resilience in adolescence.Development and psychopathology · 2023Article
- Genetics and epigenetics of stress: New avenues for an old concept.Neurobiology of stress · 2023Article
- Bidirectional Causal Associations Between Same-Sex Attraction and Psychological Distress: Testing Moderation and Mediation Effects.Behavior genetics · 2023Article
- The Impact of Multi-Quality Renewal Elements of Residence on the Subjective Well-Being of the Older Adults - A Case Study of Dalian.Psychology research and behavior management · 2023Article
- A statistical genetic investigation of psychiatric resilience.European journal of psychotraumatology · 2023Article
- Genetic factors explain a significant part of associations between adolescent well-being and the social environment.European child & adolescent psychiatry · 2022Article
- The validity of the residuals approach to measuring resilience to adverse childhood experiences.Child and adolescent psychiatry and mental health · 2022Article
- A Re-evaluation of Candidate Gene Studies for Well-Being in Light of Genome-Wide Evidence.Journal of happiness studies · 2022Article
- The Use of Demographics and Psychographics to Study Product Effects with Nutrient Supplements: Exploratory Multi-Country Data.Foods (Basel, Switzerland) · 2021Article
- Using Instrumental Variables to Measure Causation over Time in Cross-Lagged Panel Models.Multivariate behavioral researchArticle
- Exploring Health Literacy and Psychological Resilience as Moderators of Symptoms of Mental Illness Among Australian Men.American journal of men's healthArticle
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Resilience and well-being are strongly related. People with higher levels of well-being are more resilient after stressful life events or trauma and vice versa. Less is known about the underlying sources of overlap and causality between the constructs. In a sample of 11.304 twins and 2.572 siblings from the Netherlands Twin Register, we investigated the overlap and possible direction of causation between resilience (i.e. the absence of psychiatric symptoms despite negative life events) and well-being (i.e. satisfaction with life) using polygenic score (PGS) prediction, twin-sibling modelling, and the Mendelian Randomization Direction of Causality (MR-DoC) model. Longitudinal twin-sibling models showed significant phenotypic correlations between resilience and well-being (.41/.51 at time 1 and 2). Well-being PGS were predictive for both well-being and resilience, indicating that genetic factors influencing well-being also predict resilience. Twin-sibling modeling confirmed this genetic correlation (0.71) and showed a strong environmental correlation (0.93). In line with causality, both genetic (51%) and environmental (49%) factors contributed significantly to the covariance between resilience and well-being. Furthermore, the results of within-subject and MZ twin differences analyses were in line with bidirectional causality. Additionally, we used the MR-DoC model combining both molecular and twin data to test causality, while correcting for pleiotropy. We confirmed the causal effect from well-being to resilience, with the direct effect of well-being explaining 11% (T1) and 20% (T2) of the variance in resilience. Data limitations prevented us to test the directional effect from resilience to well-being with the MR-DoC model. To conclude, we showed a strong relation between well-being and resilience. A first attempt to quantify the direction of this relationship points towards a bidirectional causal effect. If replicated, the potential mutual effects can have implications for interventions to lower psychopathology vulnerability, as resilience and well-being are both negatively related to psychopathology.
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