Evidence map›Paper›PMID 33816700›Full record

ArticleAmerican journal of clinical and experimental urology2021

Genetic background but not prostatic epithelial beta-catenin influences susceptibility of male mice to testosterone and estradiol-induced urinary dysfunction.

Kyle A Wegner, Hannah Ruetten, Nicholas M Girardi, Chelsea A O'Driscoll, Jaskiran K Sandhu, Anne E Turco, Lisa L Abler, Peiqing Wang, Zunyi Wang, Dale E Bjorling and 5 more

Open access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in American journal of clinical and experimental urology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 2 institutions in 1 country.

Kyle A WegnerUniversity of Wisconsin-Madison/UMASS Boston/UT-Southwestern George M. O'Brien Center for Benign Urologic Research Madison, Wisconsin 53706, USA.
Hannah RuettenUniversity of Wisconsin-Madison/UMASS Boston/UT-Southwestern George M. O'Brien Center for Benign Urologic Research Madison, Wisconsin 53706, USA.
Nicholas M GirardiUniversity of Wisconsin-Madison/UMASS Boston/UT-Southwestern George M. O'Brien Center for Benign Urologic Research Madison, Wisconsin 53706, USA.
Chelsea A O'DriscollUniversity of Wisconsin-Madison/UMASS Boston/UT-Southwestern George M. O'Brien Center for Benign Urologic Research Madison, Wisconsin 53706, USA.
Jaskiran K SandhuUniversity of Wisconsin-Madison/UMASS Boston/UT-Southwestern George M. O'Brien Center for Benign Urologic Research Madison, Wisconsin 53706, USA.
Anne E TurcoUniversity of Wisconsin-Madison/UMASS Boston/UT-Southwestern George M. O'Brien Center for Benign Urologic Research Madison, Wisconsin 53706, USA.
Lisa L AblerUniversity of Wisconsin-Madison/UMASS Boston/UT-Southwestern George M. O'Brien Center for Benign Urologic Research Madison, Wisconsin 53706, USA.
Peiqing WangUniversity of Wisconsin-Madison/UMASS Boston/UT-Southwestern George M. O'Brien Center for Benign Urologic Research Madison, Wisconsin 53706, USA.
Zunyi WangUniversity of Wisconsin-Madison/UMASS Boston/UT-Southwestern George M. O'Brien Center for Benign Urologic Research Madison, Wisconsin 53706, USA.
Dale E BjorlingUniversity of Wisconsin-Madison/UMASS Boston/UT-Southwestern George M. O'Brien Center for Benign Urologic Research Madison, Wisconsin 53706, USA.
Rita MalinowskiUniversity of Wisconsin-Madison/UMASS Boston/UT-Southwestern George M. O'Brien Center for Benign Urologic Research Madison, Wisconsin 53706, USA.
Richard E PetersonSchool of Pharmacy, University of Wisconsin-Madison Madison, WI, USA.
Douglas W StrandUniversity of Wisconsin-Madison/UMASS Boston/UT-Southwestern George M. O'Brien Center for Benign Urologic Research Madison, Wisconsin 53706, USA.
Paul C MarkerUniversity of Wisconsin-Madison/UMASS Boston/UT-Southwestern George M. O'Brien Center for Benign Urologic Research Madison, Wisconsin 53706, USA.
Chad M VezinaUniversity of Wisconsin-Madison/UMASS Boston/UT-Southwestern George M. O'Brien Center for Benign Urologic Research Madison, Wisconsin 53706, USA.
University of Wisconsin System · USUniversity of Wisconsin–Madison · US

Funding

Role of Beta-Catenin in Urinary DysfunctionU54DK104310 · NIDDK · UNIVERSITY OF WISCONSIN-MADISON · PI RICKE, WILLIAM A · 2014 to 2023
$12.8M
Prostate inflammation increases collagen and voiding dysfunctionF30DK122686 · NIDDK · UNIVERSITY OF WISCONSIN-MADISON · PI RUETTEN, HANNAH MARGARET · 2019 to 2022
$157k
NIDDK NIH HHS F30 DK122686NIDDK NIH HHS U54 DK104310
6 · The paper itself

Abstract

Urinary voiding dysfunction in aging men can cause bothersome symptoms and irreparable tissue damage. Underlying mechanisms are not fully known. We previously demonstrated that subcutaneous, slow-release testosterone and estradiol implants (T+E2) drive a pattern of urinary voiding dysfunction in male mice that resembles that of aging men. The initial goal of this study was to test the hypothesis that prostatic epithelial beta-catenin (

Indexed as

beta-cateninBladder outlet obstructionestradioltestosteronevoiding dysfunction

Identifiers

PMID33816700
PMCPMC8012832
OpenAlexW3140997448

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.