ArticleERJ open research2021
Is laryngeal hypersensitivity the basis of unexplained or refractory chronic cough?
Article in ERJ open research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 42 citations in OpenAlex.
- Characterization of Ethyl Butyrate-Induced Cough Before and After Breath Control Techniques in Healthy Adults.American journal of speech-language pathology · 2023Trial
- Laryngopharyngeal Symptoms and Laryngopharyngeal Reflux Disease: Interdisciplinary Considerations and Management.Neurogastroenterology and motility · 2026Review
- Clarifying Terminology in Chronic Cough: The Evolving Role of Cough Hypersensitivity Syndrome.The clinical respiratory journal · 2026Review
- Behavioural cough suppression therapy: a twisting journey to frontline therapy for refractory chronic cough.ERJ open research · 2026Article
- When Refractory Is Not the End: Redefining Chronic Cough Through Tertiary Center Evaluation.Mayo Clinic proceedings. Innovations, quality & outcomes · 2026Article
- Cough-Predominant Laryngeal Hypersensitivity Syndrome in a Middle-Aged Woman: A Case Report.Cureus · 2026Article
- Observational
- Shorten swallowing time and its implication in patients with chronic cough: a prospective observational study.BMC pulmonary medicine · 2025Observational
- Voice problems in chronic cough: prevalence and implications for health and sick leave in a Northern European population.BMC pulmonary medicine · 2025Article
- Association of throat sensation severity with quality of life in patients with chronic cough.Journal of thoracic disease · 2025Article
- Real-world usage and response to gefapixant in refractory chronic cough.ERJ open research · 2025Article
- Article
- Patient-reported assessments of chronic cough in clinical trials: accessory or primary endpoints?Journal of thoracic disease · 2024Review
- Development and validation of a novel questionnaire to describe and assess sensations and triggers associated with refractory and unexplained chronic cough.BMJ open respiratory research · 2024Article
- Awareness and practices of Speech Language Pathologists (SLPs) working with chronic cough in India: a call for action.Multidisciplinary respiratory medicine · 2024Article
- Cough-hypersensitivity Syndrome-A New Paradigm in the Evaluation of Chronic Refractory Cough and Its Novel Therapeutic Horizons-A Review.Journal of community hospital internal medicine perspectives · 2024Review
- Factors influencing behavioral cough suppression therapy in children with nonspecific chronic cough.Pediatric pulmonology · 2023Observational
- Practical multidisciplinary framework for the assessment and management of patients with unexplained chronic aerodigestive symptoms.BMJ open gastroenterology · 2023Review
- Cough Sensitivity to Several External Triggers is Associated with Multiple Non-respiratory Symptoms.Lung · 2023Article
- Cough hypersensitivity and chronic cough.Nature reviews. Disease primers · 2022Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Refractory chronic cough (RCC) and unexplained chronic cough (UCC) are common problems seen in primary care and subspecialty clinics. The role of cough hypersensitivity and laryngeal dysfunction in contributing to the persistence of cough in RCC/UCC is not well recognised. Data of patients with RCC and UCC evaluated in 2019 by an interdisciplinary cough clinic led by a pulmonologist and speech-language pathology team was reviewed. Patients completed validated questionnaires including the Leicester cough questionnaire (LCQ), voice handicap index (VHI) and dyspnoea index (DI) questionnaire at initial encounter. Presence of cough hypersensitivity was based upon a history of allotussia and hypertussia. Laryngeal dysfunction was diagnosed in those with a history of laryngeal paresthesias, throat clearing, voice abnormalities, upper airway dyspnoea and documentation of functional or anatomic laryngeal abnormalities on nasoendoscopy. Of the 60 UCC/RCC patients analysed, 75% of patients were female and 85% were over 40 years of age. Cough hypersensitivity was documented in all patients and multiple cough triggers occurred in 75% of patients. 95%, 50% and 25% of patients reported laryngeal paresthesias, voice abnormalities and upper airway dyspnoea, respectively. Significant associations between LCQ and VHI and DI scores occurred when adjusting for age, sex, ethnicity and body mass index. Laryngeal functional abnormalities were documented on 44 out of 60 patients on nasoendoscopy. Hypertussia, allotussia and laryngeal dysfunction are common in patients with RCC and UCC. Evaluation of UCC and RCC can delineate laryngeal hypersensitivity and allows appropriate treatment to be directed at this phenotype.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.