Evidence map›Paper›PMID 33816516›Full record

ArticleFrontiers in medicine2021

Detecting SARS-CoV-2 in the Breath of COVID-19 Patients.

Xiaoguang Li, Jing Li, Qinggang Ge, Yuguang Du, Guoqiang Li, Wei Li, Tong Zhang, Lei Tan, Runqiang Zhang, Xiaoning Yuan and 9 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
4.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 32 citations in OpenAlex.

  1. A study of 9 common breath VOCs in 504 healthy subjects using PTR-TOF-MS.Metabolomics : Official journal of the Metabolomic Society · 2024
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  14. Detection of SARS-CoV-2 RNA in Bivalve Mollusks by Droplet Digital RT-PCR (dd RT-PCR).International journal of environmental research and public health · 2022
    Article
  15. Article
  16. Article
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  18. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 8 institutions in 1 country.

Xiaoguang LiDepartment of Infectious Diseases, Peking University Third Hospital, Beijing, China.
Jing LiCAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.
Qinggang GeDepartment of Infectious Diseases, Peking University Third Hospital, Beijing, China.
Yuguang DuState Key Laboratory of Biochemical Engineering, Institute of Process Engineering and Innovation Academy for Green Manufacture, Chinese Academy of Sciences, Beijing, China.
Guoqiang LiCommune of Scientific Engineers, Institute of Physics, Chinese Academy of Sciences, Beijing, China.
Wei LiState Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.
Tong ZhangDepartment of Infectious Diseases, YouAn Hospital, Capital Medical University, Beijing, China.
Lei TanState Key Laboratory of Hydroscience and Engineering, Department of Energy and Power Engineering, Tsinghua University, Beijing, China.
Runqiang ZhangState Key Laboratory of Hydroscience and Engineering, Department of Energy and Power Engineering, Tsinghua University, Beijing, China.
Xiaoning YuanDepartment of Infectious Diseases, Peking University Third Hospital, Beijing, China.
He ZhangCAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.
Chen ZhangState Key Laboratory of Biochemical Engineering, Institute of Process Engineering and Innovation Academy for Green Manufacture, Chinese Academy of Sciences, Beijing, China.
Wenjun LiuCAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.
Wei DingCommune of Scientific Engineers, Institute of Physics, Chinese Academy of Sciences, Beijing, China.
Liang SunCommune of Scientific Engineers, Institute of Physics, Chinese Academy of Sciences, Beijing, China.
Ke ChenCAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.
Zhuo WangState Key Laboratory of Biochemical Engineering, Institute of Process Engineering and Innovation Academy for Green Manufacture, Chinese Academy of Sciences, Beijing, China.
Ning ShenDepartment of Infectious Diseases, Peking University Third Hospital, Beijing, China.
Jun LuCommune of Scientific Engineers, Institute of Physics, Chinese Academy of Sciences, Beijing, China.
Institute of Physics · CNChinese Academy of Sciences · CNInstitute of Process Engineering · CNInstitute of Microbiology · CNPeking University · CNPeking University Third Hospital · CNTsinghua University · CNBeijing YouAn Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In the COVID-19 outbreak year 2020, a consensus was reached on the fact that SARS-CoV-2 spreads through aerosols. However, finding an efficient method to detect viruses in aerosols to monitor the risk of similar infections and enact effective control remains a great challenge. Our study aimed to build a swirling aerosol collection (SAC) device to collect viral particles in exhaled breath and subsequently detect SARS-CoV-2 using reverse transcription polymerase chain reaction (RT-PCR). Laboratory tests of the SAC device using aerosolized SARS-CoV-2 pseudovirus indicated that the SAC device can produce a positive result in only 10 s, with a collection distance to the source of 10 cm in a biosafety chamber, when the release rate of the pseudovirus source was 1,000,000 copies/h. Subsequent clinical trials of the device showed three positives and 14 negatives out of 27 patients in agreement with pharyngeal swabs, and 10 patients obtained opposite results, while no positive results were found in a healthy control group (

Indexed as

COVID-19exhaled breathSARS-CoV-2swirling aerosol collectorvirus detection

Identifiers

PMID33816516
PMCPMC8010128
OpenAlexW3137314536

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.