Evidence map›Paper›PMID 33816507›Full record

ReviewFrontiers in cell and developmental biology2021

When the Ends Justify the Means: Regulation of Telomere Addition at Double-Strand Breaks in Yeast.

Remington E Hoerr, Katrina Ngo, Katherine L Friedman

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in cell and developmental biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.6field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. A comprehensive map of hotspots of de novo telomere addition inbioRxiv : the preprint server for biology · 2023
    Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Remington E HoerrDepartment of Biological Sciences, Vanderbilt University, Nashville, TN, United States.
Katrina NgoDepartment of Biological Sciences, Vanderbilt University, Nashville, TN, United States.
Katherine L FriedmanDepartment of Biological Sciences, Vanderbilt University, Nashville, TN, United States.
Vanderbilt University · US

Funding

TRAINING PROGRAM IN CELLULAR, BIOCHEMICAL, &MOLECULAR ST32GM008554 · NIGMS · VANDERBILT UNIVERSITY · PI PATTON, JAMES G. · 1995 to 2020
$7.4M
Cellular, Biochemical and Molecular Sciences Training ProgramT32GM137793 · NIGMS · VANDERBILT UNIVERSITY · PI Katherine Louise Friedman, TODD R GRAHAM · 2021 to 2026
$2.6M
Hotspots of de novo telomere addition as mediators of genomic instability in yeastR01GM123292 · NIGMS · VANDERBILT UNIVERSITY · PI FRIEDMAN, KATHERINE LOUISE · 2017 to 2020
$1.3M
NIGMS NIH HHS R01 GM123292NIGMS NIH HHS T32 GM008554NIGMS NIH HHS T32 GM137793
6 · The paper itself

Abstract

Telomeres, repetitive sequences located at the ends of most eukaryotic chromosomes, provide a mechanism to replenish terminal sequences lost during DNA replication, limit nucleolytic resection, and protect chromosome ends from engaging in double-strand break (DSB) repair. The ribonucleoprotein telomerase contains an RNA subunit that serves as the template for the synthesis of telomeric DNA. While telomere elongation is typically primed by a 3' overhang at existing chromosome ends, telomerase can act upon internal non-telomeric sequences. Such

Indexed as

de novo telomere additionDNA repairPif1telomerasetelomere

Identifiers

PMID33816507
PMCPMC8012806
OpenAlexW3138046965

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.