Evidence map›Paper›PMID 33816332›Full record

ArticleFrontiers in cellular and infection microbiology2021

Auranofin Resistance in

Christopher I Ma, James A Tirtorahardjo, Sharon Jan, Sakura S Schweizer, Shawn A C Rosario, Yanmiao Du, Jerry J Zhang, Naomi S Morrissette, Rosa M Andrade

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.1field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 15 citations in OpenAlex.

  1. Elucidating the Role ofBiomolecules · 2025
    Article
  2. Review
  3. Article
  4. Article
  5. Structure ofInternational journal of molecular sciences · 2023
    Article
  6. Review
  7. Inhibition ofFrontiers in cellular and infection microbiology · 2022
    Article
  8. Antioxidants (Basel, Switzerland) · 2021
    Article
  9. Auranofin Resistance inFrontiers in cellular and infection microbiology · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Christopher I MaDivision of Infectious Diseases, Department of Medicine, University of California Irvine, Irvine, CA, United States.
James A TirtorahardjoDepartment of Microbiology and Molecular Genetics, University of California Irvine, Irvine, CA, United States.
Sharon JanDepartment of Microbiology and Molecular Genetics, University of California Irvine, Irvine, CA, United States.
Sakura S SchweizerDivision of Infectious Diseases, Department of Medicine, University of California Irvine, Irvine, CA, United States.
Shawn A C RosarioSchool of Biological Sciences, University of California Irvine, Irvine, CA, United States.
Yanmiao DuSchool of Biological Sciences, University of California Irvine, Irvine, CA, United States.
Jerry J ZhangDivision of Infectious Diseases, Department of Medicine, University of California Irvine, Irvine, CA, United States.
Naomi S MorrissetteDepartment of Molecular Biology and Biochemistry, University of California Irvine, Irvine, CA, United States.
Rosa M AndradeDivision of Infectious Diseases, Department of Medicine, University of California Irvine, Irvine, CA, United States.
University of California, Irvine · US

Funding

Univ.of Calif., Irvine Cancer Center Support GrantP30CA062203 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI Christine Hui · 1994 to 2026
$57.9M
Thio-dependent Antioxidants: A Novel Drug Target for Toxoplasma GondiiK08AI102989 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ANDRADE, ROSA M. · 2014 to 2018
$965k
PacBio RS Single Molecule, Real-Time (SMRT) DNA SequencerS10OD010794 · OD · UNIVERSITY OF CALIFORNIA-IRVINE · PI SANDMEYER, SUZANNE · 2012 to 2012
$600k
High-Throughput DNA SequencerS10OD021718 · OD · UNIVERSITY OF CALIFORNIA-IRVINE · PI SANDMEYER, SUZANNE · 2016 to 2016
$600k
High Throughput DNA SequencerS10RR025496 · NCRR · UNIVERSITY OF CALIFORNIA-IRVINE · PI SANDMEYER, SUZANNE · 2009 to 2009
$500k
NCI NIH HHS P30 CA062203NCRR NIH HHS S10 RR025496NIAID NIH HHS K08 AI102989NIH HHS S10 OD010794NIH HHS S10 OD021718
6 · The paper itself

Abstract

Auranofin, a reprofiled FDA-approved drug originally designed to treat rheumatoid arthritis, has emerged as a promising anti-parasitic drug. It induces the accumulation of reactive oxygen species (ROS) in parasites, including

Indexed as

ParasitesToxoplasmaAnimalsAuranofinReactive Oxygen SpeciesThioredoxin-Disulfide ReductaseAuranofinReactive Oxygen SpeciesThioredoxin-Disulfide Reductaseanti-parasiticauranofingoldredoxrepurposingresistancesuperoxideToxoplasma

Identifiers

PMID33816332
PMCPMC8017268
OpenAlexW3138863655

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.