ArticleFrontiers in oncology2021
The Impact of Prolonged Mechanical Ventilation on Overall Survival in Patients With Surgically Treated Brain Metastases.
Article in Frontiers in oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed, 16 citations in OpenAlex.
- Prognostic Value of Perioperative Anemia in Neurosurgical-Oncological Treatment of Spinal Metastases.International journal of cancer · 2026Article
- Return to Intended Oncologic Therapy After Brain Metastasis Surgery: Mapping the Early Postoperative Pathway.Current oncology (Toronto, Ont.) · 2026Article
- Early versus delayed postoperative extubation after elective neurosurgical treatment of brain metastasis.Journal of cancer research and clinical oncology · 2025Article
- Bone mineral density as potential individual prognostic biomarker in patients with neurosurgically treated spinal metastasis.Journal of cancer research and clinical oncology · 2025Article
- Transient and permanent hydrocephalus following resection of brain metastases located in the posterior fossa: incidence, risk factors and the necessity of perioperative external ventricular drainage placement.Journal of neuro-oncology · 2025Article
- Patients with Leptomeningeal Carcinomatosis and Hydrocephalus-Feasibility of Combined Ventriculoperitoneal Shunt and Reservoir Insertion for Intrathecal Chemotherapy.Current oncology (Toronto, Ont.) · 2024Article
- Synchronous versus metachronous spinal metastasis: a comparative study of survival outcomes following neurosurgical treatment.Journal of cancer research and clinical oncology · 2024Article
- Incurring detriments of unplanned readmission to the intensive care unit following surgery for brain metastasis.Neurosurgical review · 2023Article
- Postoperative prolonged mechanical ventilation in patients with surgically treated pyogenic spondylodiscitis: a surrogate endpoint for early postoperative mortality.Neurosurgical review · 2023Article
- Survival after resection of brain metastasis: impact of synchronous versus metachronous metastatic disease.Journal of neuro-oncology · 2023Article
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- Postoperative prolonged mechanical ventilation correlates to poor survival in patients with surgically treated spinal metastasis.Frontiers in oncology · 2022Article
- Preoperative Metastatic Brain Tumor-Associated Intracerebral Hemorrhage Is Associated With Dismal Prognosis.Frontiers in oncology · 2021Article
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Authors and funding
19 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveSurgical resection represents a common treatment modality in patients with brain metastasis (BM). Postoperative prolonged mechanical ventilation (PMV) might have an enormous impact on the overall survival (OS) of these patients suffering from advanced cancer disease. We therefore have analyzed our institutional database with regard to a potential impact of PMV on OS of patients who had undergone surgery for brain metastases.
methods360 patients with surgically treated brain metastases were included. The definition of PMV consisted of postoperative mechanical ventilation lasting for more than 48 hours. Analysis of survival incorporating established prognostic factors such as age, location of BM, and preoperative physical status was performed.
results14 of 360 patients with BM (4%) suffered from postoperative PMV after surgical treatment of BM. Patients with PMV presented in a significantly more impaired neurological condition preoperatively than patients without (p<0.0001). Multivariate analysis determined PMV to be a significant prognostic factor for OS after surgical treatment in patients with BM, independent of other predictive factors (p<0.0001).
conclusionsThe present study demonstrates postoperative PMV as significantly related to poor OS in patients with surgically treated BM. Postoperative PMV is a so far underestimated prognostic predictor, but might be utilized for optimized patient management early in the postoperative phase. For this purpose, the results of the present study should encourage the initiation of further scientific efforts.
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