ArticleFrontiers in oncology2021
Computed Tomography Features of Gastric Cancer Patients With DNA Mismatch Repair Deficiency.
Article in Frontiers in oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 12 citations in OpenAlex.
- A radiomics signature derived from CT imaging to predict MSI status and immunotherapy outcomes in gastric cancer: a multi-cohort study.BMC cancer · 2024Article
- Nomogram based on dual-energy CT-derived extracellular volume fraction for the prediction of microsatellite instability status in gastric cancer.Frontiers in oncology · 2024Article
- A noninvasive nomogram model based on CT features to predict DNA mismatch repair deficiency in gastric cancer.Frontiers in oncology · 2023Article
- CT-based radiomic nomogram for preoperative prediction of DNA mismatch repair deficiency in gastric cancer.Frontiers in oncology · 2022Article
- The Clinicopathological Characteristics and Prognoses of dMMR Gastric Adenocarcinoma Patients.Gastroenterology research and practice · 2021Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo explore the computed tomography (CT) features of gastric cancer (GC) patients with DNA mismatch repair deficiency (dMMR). MATERIALS AND
methodsThis study reviewed the clinical and CT features of GC patients with dMMR, confirmed by the postoperative results, between September 2017 and December 2019. The expression pattern of MMR major proteins (MLH1, MSH2, MSH6, and PMS2) in immunohistochemistry was used to confirm the MMR status in GC tissues. The correlation between pre-treatment CT features and MMR status was statistically analyzed.
resultsA total of 28 patients with GC were diagnosed as dMMR in our study, and 49 patients were MMR-proficient (pMMR). The tumor locations were significantly different between the dMMR and pMMR groups (p = 0.006). The CT tumor thickness, CT long and short diameters of the largest lymph node, and the number of lymph nodes on CT of the dMMR group were significantly different from the pMMR group.
conclusionThe dMMR GC exhibited a lower stomach location, smaller tumor thickness and lymph node diameter, and fewer lymph nodes on CT imaging.
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