ArticleQuantitative imaging in medicine and surgery2021
Shear wave-based sound touch elastography in liver fibrosis assessment for patients with autoimmune liver diseases.
Article in Quantitative imaging in medicine and surgery, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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12 citing papers in PubMed, 19 citations in OpenAlex.
- Article
- Development of a predictive nomogram for post-liver transplantation complications using clinical parameters and liver stiffness measured by sound touch elastography.Annals of medicine · 2025Article
- Modern ultrasound techniques for diagnosing liver steatosis and fibrosis: A systematic review with a focus on biopsy comparison.World journal of hepatology · 2025Article
- Evaluation of hepatic steatosis in obese children and adolescents using immune-inflammatory markers and shear wave elastography.Journal of ultrasonography · 2025Article
- Systemic treatment type is not associated with abnormal post-treatment noninvasive liver stiffness measurement in psoriasis.Frontiers in immunology · 2024Article
- CT and MR imaging of primary biliary cholangitis: a pictorial review.Insights into imaging · 2023Review
- Diagnosis of liver fibrosis and liver function reserve through non-invasive multispectral photoacoustic imaging.Photoacoustics · 2023Article
- L-distance ratio: a new distance ratio-based evaluation method for the diagnosis of cirrhosis using enhanced computed tomography.Quantitative imaging in medicine and surgery · 2023Article
- A novel prediction tool based on shear wave elastography, gallbladder ultrasound, and serum biomarkers for the early diagnosis of biliary atresia in infants younger than 60 days old.Quantitative imaging in medicine and surgery · 2023Article
- Efficacy of shear wave dispersion imaging for viscoelastic assessment of the liver in acute graft-versus-host disease rats.Quantitative imaging in medicine and surgery · 2022Article
- A model based on two-dimensional shear wave elastography for acute-on-chronic liver failure development in patients with acutely decompensated hepatitis B cirrhosis.Quantitative imaging in medicine and surgery · 2022Article
- Shear wave elastography using sound touch elastography and supersonic shear imaging for liver measurements: a comparative study.Quantitative imaging in medicine and surgery · 2022Article
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Authors and funding
8 authors at 3 institutions in 2 countries.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundShear wave-based ultrasonic elastography (USE) has been widely used for the assessment of liver fibrosis in patients with chronic liver diseases (CLD). However, diagnostic criteria and accuracy vary between different etiologies and specific elastography techniques. We aimed to evaluate the tissue stiffness measured by shear wave-based sound touch elastography (STE) in staging liver fibrosis in patients with autoimmune liver diseases (AILD).
methodsOne hundred and two AILD patients who had undergone STE liver stiffness measurements (LSMs) by using a Resona 7 ultrasound system were retrospectively studied. With the Scheuer liver fibrosis staging system as the reference, we investigated the diagnostic performance and cutoff values of STE measured liver stiffness in staging liver fibrosis through receiver operating characteristic (ROC) curve analysis. Moreover, comparisons of areas under the curve (AUCs) were made between LSMs and calculated biomarker scores, including the aspartate aminotransferase (AST)-to-platelet ratio index (APRI), and fibrosis-4 (FIB-4) index.
resultsMedian LSMs increased with the advancing fibrosis stages with values of 6.89 kPa (1.51 m/s), 8.00 kPa (1.63 m/s), 9.60 kPa (1.79 m/s), 11.37 kPa (1.95 m/s) and 14.50 kPa (2.20 m/s), from stage 0 to stage 4 respectively. The cutoff values of STE for identifying significant fibrosis (≥ stage 2), severe fibrosis (≥ stage 3) and cirrhosis (stage 4) were 9.07 kPa (1.74 m/s), 9.97 kPa (1.82 m/s) and 10.48 kPa (1.87 m/s), respectively, with corresponding sensitivity of 79.1%, 93.3%, and 100%; specificity of 80.0%, 70.8% and 71.8%. The AUCs of LSMs in identifying fibrosis ≥ stage 2, ≥ stage 3 and stage 4 (0.82, 0.87, and 0.91, respectively) were significantly higher than that of APRI (0.67, 0.64, and 0.72, respectively) and FIB-4 (0.70, 0.68, and 0.75, respectively) (all P<0.05).
conclusionsLSM obtained by STE exhibited its good capability to evaluate liver fibrosis stages in patients with AILD. As a noninvasive modality for liver fibrosis staging, STE is superior to APRI and FIB-4 biomarker scores.
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