ArticleCurrent epidemiology reports2020
Sex-specific neurotoxic effects of early-life exposure to fluoride: A review of the epidemiologic and animal literature.
Article in Current epidemiology reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Fluoride Intake Through Dental Care Products: A Systematic Review.Frontiers in oral health · 2022Pooled it
- Water Fluoridation Risks or Benefits: Summary of the Symposium Presented During the Enamel 11 Meeting Held in Paris France.Calcified tissue international · 2026Article
- Fluoride Concentration and pH Levels in Non-/Low-Alcoholic Beers.Biological trace element research · 2026Article
- Prenatal fluoride exposure and autistic behaviors in preschool-aged children: the Maternal-Infant Research on Environmental Chemicals (MIREC) cohort study.Environmental health : a global access science source · 2025Article
- Early Childhood Exposures to Fluorides and Cognitive Neurodevelopment: A Population-Based Longitudinal Study.Journal of dental research · 2025Article
- Water Fluoridation and Birth Outcomes in California.Environmental health perspectives · 2024Article
- Fluoride exposure and thyroid hormone levels in pregnancy: The MIREC cohort.Environment international · 2024Article
- Fluoride exposure and hypothyroidism in a Canadian pregnancy cohort.The Science of the total environment · 2023Article
- Prenatal exposure to polycyclic aromatic hydrocarbons is not associated with behavior problems in preschool and early school-aged children: A prospective multi-cohort study.Environmental research · 2023Article
- Iodine Status in Pregnant Women Having Urinary Fluoride in Contaminated Areas: A Case Study of Phayao Province.Journal of environmental and public health · 2023Article
- Domain-specific effects of prenatal fluoride exposure on child IQ at 4, 5, and 6-12 years in the ELEMENT cohort.Environmental research · 2022Article
- Iodine Status Modifies the Association between Fluoride Exposure in Pregnancy and Preschool Boys' Intelligence.Nutrients · 2022Article
- Maternal fluoride exposure, fertility and birth outcomes: The MIREC cohort.Environmental advances · 2022Article
- Fluoride exposure during early adolescence and its association with internalizing symptoms.Environmental research · 2022Article
- A Benchmark Dose Analysis for Maternal Pregnancy Urine-Fluoride and IQ in Children.Risk analysis : an official publication of the Society for Risk Analysis · 2022Article
- Impacts of Fluoride Neurotoxicity and Mitochondrial Dysfunction on Cognition and Mental Health: A Literature Review.International journal of environmental research and public health · 2021Review
- Dietary fluoride intake during pregnancy and neurodevelopment in toddlers: A prospective study in the progress cohort.Neurotoxicology · 2021Article
- Critical windows of fluoride neurotoxicity in Canadian children.Environmental research · 2021Article
- A Benchmark Dose Analysis for Maternal Pregnancy Urine-Fluoride and IQ in Children.medRxiv : the preprint server for health sciences · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
purpose of reviewA growing body of evidence suggests adverse neurodevelopmental effects of early-life exposure to fluoride that may differ depending on timing of exposure and sex of the exposed. We conducted a literature search to identify the animal and human epidemiologic studies that examined sex-specific neurodevelopmental differences in response to prenatal and postnatal exposure to fluoride. RECENT
findingsSix of 138 animal studies and 15 of 106 human epidemiologic studies tested for sex-specific effects. Prenatal exposure to fluoride was associated with a male susceptibility to adverse behavioural effects in four of six animal studies and lower IQ in one of three prospective cohort studies. The body of evidence examining sex-effects associated with postnatal fluoride exposure was scarce, and many animal and cross-sectional human studies were considered to have a high risk of bias. SUMMARY: Compared to females, male offspring appear to be more sensitive to prenatal, but not postnatal, exposure to fluoride. We discuss several sex-specific mechanisms and emphasize the need for future research.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.