Evidence map›Paper›PMID 33815958›Full record

ArticleAmerican journal of clinical and experimental immunology2021

The effect of a cow's milk-free diet on asthma control in children: a quasi-experimental study.

Sepideh Darougar, Mahboubeh Mansouri, Solmaz Hassani, Mohammad Reza Sohrabi, Paniz Hashemitari

Open access · greenAbstract read
In one paragraph

Article in American journal of clinical and experimental immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Sepideh DarougarDepartment of Pediatrics, Tehran Medical Sciences Branch, Islamic Azad University Tehran, Iran.
Mahboubeh MansouriDepartment of Allergy and Clinical Immunology, Mofid Children Hospital, Shahid Beheshti University of Medical Sciences Tehran, Iran.
Solmaz HassaniMofid Children Hospital, Shahid Beheshti University of Medical Sciences Tehran, Iran.
Mohammad Reza SohrabiSocial Determinants of Health Research Center, Shahid Beheshti University of Medical Sciences Tehran, Iran.
Paniz HashemitariHumanitas University Milan, Italy.
Shahid Beheshti University of Medical Sciences · IRHumanitas University · ITIslamic Azad University Medical Branch of Tehran · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundFood allergy which usually develops in the first year of life is a risk factor for persistent asthma in young children. Cow's milk has been demonstrated to be the most commonly identified food allergen in children. Considering the central role of non-IgE-mediated food allergies in the development of hidden gastroesophageal reflux and consequently asthma, we evaluated the effect of eliminating food allergens to better control asthma.

methodA total of eighty infants and children up to the age of 12 referred to the Asthma Clinic of Mofid Children Hospital for a period of one year were enrolled in this study. In those patients whose asthma remained uncontrolled (Childhood Asthma Control Test ≤19) despite a 2-week period of treatment, we advocated a 2-week-diet based on eliminating cow's milk in conjunction with asthma conventional therapy. For breast-fed infants, mothers were requested to eliminate these products from their daily intake regimens and for formula-fed infants, the elemental based formula was started.

resultsThree of the patients were lost in follow-up and six of them were excluded from the study because of non-compliance. The Asthma Control Test score which was less than or equal to 19 in the entire study population, increased to 20 or more after we began a diet based on the elimination of cow's milk in all but 13 participants.

conclusionTo conclude, the results were promising, demonstrating that a cow's milk protein elimination diet is a prudent approach in the management of patients with recalcitrant asthma, and can be considered as the missing link in asthma treatment.

Indexed as

Asthmaatopychildhoodchildrencow’s milkdietfood allergens

Identifiers

PMID33815958
PMCPMC8012302
OpenAlexW3141140341

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.