Evidence map›Paper›PMID 33815929›Full record

ArticleAmerican journal of cardiovascular disease2021

Impact of oral

Richard Onalo, Antoinette Cilliers, Peter Cooper

Registry-linked trialOpen access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in American journal of cardiovascular disease, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04839354 (Sickle Cell Disease Treatment With Arginine Therapy), which is not on this map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04839354 phase3completednot on this map

Sickle Cell Disease Treatment With Arginine Therapy (STArT) Trial

TypeinterventionalSponsorClaudia R. MorrisRan2021 to 2024Enrolled271ConditionsSickle Cell DiseaseArmsL-Arginine Hydrochloride, Normal saline
3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 9 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Review
  4. Sickle Cell Disease.Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie · 2024
    Review
  5. Article
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Richard OnaloDepartment of Paediatrics, Faculty of Clinical Sciences, University of Abuja, Nigeria and Department of Paediatrics & Child Health, Faculty of Clinical Sciences, University of The Witwatersrand Johannesburg, South Africa.
Antoinette CilliersDivision of Paediatric Cardiology, Department of Paediatrics, Chris Hani Baragwanath Academic Hospital, University of The Witwatersrand Johannesburg, South Africa.
Peter CooperDepartment of Paediatrics & Child Health, University of The Witwatersrand Johannesburg, South Africa.
University of the Witwatersrand · ZA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sickle cell anaemia (SCA) patients generally have lower blood pressures compared to those with the AA haemoglobin genotype. However, during vaso-occlusive crises (SCA-VOC), blood pressures (BP) may elevate transiently to levels beyond the 95

methodsA double-blind RCT of oral

resultsSixty-six children (57.6% male) were randomized into

conclusionsHigh blood pressure (≥95

Indexed as

blood pressureNigerian childrenOral argininesickle cell anemia

Identifiers

PMID33815929
PMCPMC8012291
OpenAlexW3148000782

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.