Evidence map›Paper›PMID 33815924›Full record

ArticleAmerican journal of cardiovascular disease2021

Exercise-induced haemoglobin oxygen desaturation in patients with SCD.

Charles Antwi-Boasiako, Chamila P Asare, Jane S Afriyie-Mensah, Charles Hayfron-Benjamin, Isaac Nuako, Robert Aryee, Gifty Boatemaa Dankwah, Michael M Asare, Kevin Adutwum-Ofosu

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In one paragraph

Article in American journal of cardiovascular disease, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 54% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Charles Antwi-BoasiakoDepartment of Physiology, University of Ghana Medical School, University of Ghana Accra, Ghana.
Chamila P AsareDepartment of Anaesthesia, Korle-Bu Teaching Hospital Accra, Ghana.
Jane S Afriyie-MensahDepartment of Anaesthesia, Lekma Hospital Accra, Ghana.
Charles Hayfron-BenjaminDepartment of Physiology, University of Ghana Medical School, University of Ghana Accra, Ghana.
Isaac NuakoDepartment of Anaesthesia, 37 Military Hospital Accra, Ghana.
Robert AryeeDepartment of Physiology, University of Ghana Medical School, University of Ghana Accra, Ghana.
Gifty Boatemaa DankwahDepartment of Physiology, University of Ghana Medical School, University of Ghana Accra, Ghana.
Michael M AsareDepartment of Anatomy, University of Ghana Medical School, University of Ghana Accra, Ghana.
Kevin Adutwum-OfosuDepartment of Medicine and Therapeutics, University of Ghana Medical School, University of Ghana Accra, Ghana.
University of Ghana · GHKorle Bu Teaching Hospital · GH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPatients with sickle cell disease (SCD) may experience severe clinical complications when there is low tissue oxygenation due to the increased risk of the polymerization of haemoglobin S in deoxygenated environment. The predictors of oxygen desaturation after exercise is not clear in patients with SCD. The current study compared lung function and six-minute walk test (6MWT) between SCD patients with oxygen desaturation after exercise and those without oxygen desaturation. METHODOLOGY: A cross-sectional study was conducted among adults with SCD (with HbSS and HbSC genotypes) at a large tertiary hospital in Accra, Ghana. Lung function and exercise tolerance (using the 6MWT) were performed for all the study subjects (n=119). Venous blood was collected from all the study subjects for determination of some haemolytic markers. Oxygen saturation was assessed before and after the 6MWT for all the study subjects, and individuals who had oxygen desaturation of ≥3% after the 6MWT were considered as having exercise-induced haemoglobin oxygen desaturation (EIHOD). The lung function and 6MWT were compared between these two groups. Predictors of EIHOD were determined in both HbSC and HbSS patients.

resultsThe prevalence of EIHOD in the HbSS and HbSC adults were 41% and 36.1% respectively. Haemoglobin, aspartate amino transaminase, indirect bilirubin, lactate dehydrogenase and six-minute walk distance did not differ in both HbSS and HbSC patients. Decreasing haemoglobin is a predictor of EIHOD in HbSC adults but not HbSS patients. Lung function abnormalities did not predict EIHOD in both HbSS and HbSC patients.

conclusionThe study demonstrates that SCD patients with EIHOD have similar degree of haemolysis and lung function when compared to those without EIHOD.

Indexed as

lung functionoxygen desaturationSickle cell diseasesix-minute walk test

Identifiers

PMID33815924
PMCPMC8012294
OpenAlexW3147764447

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.