ArticleJournal of health & pollution2021
Bisphenol A-induced Alterations in Different Stages of Spermatogenesis and Systemic Toxicity in Albino Mice (
Article in Journal of health & pollution, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.
- A Systematic Review on the Phytoremediation Potential of Grass Species in Ethiopia.TheScientificWorldJournal · 2026Pooled it
- Transcriptomic analysis of mouse testes with disordered spermatogenesis induced by high-dose BPA exposure during puberty.Molecular biology reports · 2026Article
- One-step growth of Cu-doped carbon dots in amino-modified carbon nanotube-modified electrodes for sensitive electrochemical detection of BPA.Mikrochimica acta · 2024Article
- The Ameliorative Impact ofIranian journal of medical sciences · 2023Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBisphenol A (BPA) is known to alter sperm morphology, but information is limited on the most susceptible stage(s) of spermatogenesis, especially in mice.
objectivesThis study investigated the reproductive, biochemical, and hematological changes caused by exposure to BPA in male albino mice. The genotoxicity of BPA to the six stages of spermatogenesis in mice was determined.
methodsMice were exposed orally to BPA at 0.5, 1.0, 2.0, and 5.0 mg/kg bw doses for 5 days and assessed for sperm morphology after 35 days. Based on the result, the second group of mice was exposed to BPA at 1.0 mg/kg bw dose for 5 days, their spermatozoa were assessed for sperm morphology based on BPA exposure at the 6 maturation stages of spermatogenesis: spermatozoa, elongating spermatids, round spermatids, secondary spermatocytes, primary spermatocytes, and spermatogonia. Biochemical and hematological analyses of the blood of exposed mice were also carried out.
resultsThe results showed that BPA induced concentration-dependent, significantly (p<0.05) increased sperm cell abnormalities at three of the four concentrations tested, with the exception of 0.5 mg/kg bw, in comparison with the negative control. The highest frequency of sperm aberrations was induced in spermatozoa exposed to BPA while at the primary spermatocytes. The order of induced sperm abnormality at the different stages of exposure was: primary spermatocytes > elongating spermatids > spermatozoa > spermatogonia > round spermatids > secondary spermatocytes. The results of the biochemical analysis showed significantly (p<0.05) increased serum urea, creatinine, and alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activities with a concomitant decrease in total protein content at the various stages of spermatogenesis. In addition, the results for hematological parameters showed several significant (p<0.05) modulations in mice exposed to BPA.
conclusionsThese data showed that BPA is most toxic to primary spermatocytes and alterations of biochemical and hematological parameters might be the mechanisms of induced toxicity. ETHICS APPROVAL: The Research Ethics Committee, Federal University of Technology, Akure approved the study protocols. COMPETING INTERESTS: The authors declare no competing financial interests.
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