ReviewAging and disease2021
Metabolomics Signatures of Aging: Recent Advances.
Review in Aging and disease, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
49 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Sex differences in pharmacological interventions and their effects on lifespan and healthspan outcomes: a systematic review.Frontiers in aging · 2023Pooled it
- Dietary phytosterol alleviates adverse effects caused by high-carbohydrate diets on growth performance, antioxidant capacity, glucolipid metabolism, and metabolomics in largemouth bass (Micropterus salmoides) juveniles.Fish physiology and biochemistry · 2026Article
- Metabolomic Profiling ofJournal of fungi (Basel, Switzerland) · 2026Article
- Urinary metabolic age from high-resolution nuclear magnetic resonance spectroscopy reveals longitudinal aging patterns.The journals of gerontology. Series A, Biological sciences and medical sciences · 2026Article
- Lifespan-Extending Endogenous Metabolites.Aging cell · 2026Review
- Metabolomic sweet spot clock predicts mortality and age-related diseases in the Canadian Longitudinal Study on Aging.Communications medicine · 2026Article
- Different ages of gut microbiota diversity and metabolic pattern in rhesus macaques.Frontiers in microbiology · 2026Article
- Precision geronutrition: personalized nutritional strategies to extend healthy lifespan.BMB reports · 2026Review
- Advances in anti-aging Drug research leveraging multi-omics and artificial intelligence.Frontiers in aging · 2026Review
- "Immunopause" no more: exercise to counter immunosenescence in aging.Immunity & ageing : I & A · 2025Review
- Genetic architecture and analysis practices of circulating metabolites in the NHLBI Trans-Omics for Precision Medicine Program.American journal of human genetics · 2025Article
- The silent saboteur: oxidative stress and the path to cognitive dysfunction.Neurodegenerative disease management · 2025Review
- Towards Precision Aging Biology: Single-Cell Multi-Omics and Advanced AI-Driven Strategies.Aging and disease · 2025Review
- Influence of Ageing on the Pharmacodynamics and Pharmacokinetics of Chronically Administered Medicines in Geriatric Patients: A Review.Clinical pharmacokinetics · 2025Review
- The impact of aging on neutrophil functions and the contribution to periodontitis.International journal of oral science · 2025Review
- Review
- Metabolite signatures of chronological age, aging, survival, and longevity.Cell reports · 2024Article
- Article
- Aging and Pathological Conditions Similarity Revealed by Meta-Analysis of Metabolomics Studies Suggests the Existence of the Health and Age-Related Metapathway.Metabolites · 2024Article
- Unveiling the Metabolic Trajectory of Pig Feces Across Different Ages and Senescence.Metabolites · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Metabolomics is the latest state-of-the-art omics technology that provides a comprehensive quantitative profile of metabolites. The metabolites are the cellular end products of metabolic reactions that explain the ultimate response to genomic, transcriptomic, proteomic, or environmental changes. Aging is a natural inevitable process characterized by a time-dependent decline of various physiological and metabolic functions and are dominated collectively by genetics, proteomics, metabolomics, environmental factors, diet, and lifestyle. The precise mechanism of the aging process is unclear, but the metabolomics has the potential to add significant insight by providing a detailed metabolite profile and altered metabolomic functions with age. Although the application of metabolomics to aging research is still relatively new, extensive attempts have been made to understand the biology of aging through a quantitative metabolite profile. This review summarises recent developments and up-to-date information on metabolomics studies in aging research with a major emphasis on aging biomarkers in less invasive biofluids. The importance of an integrative approach that combines multi-omics data to understand the complex aging process is discussed. Despite various innovations in metabolomics and metabolite associated with redox homeostasis, central energy pathways, lipid metabolism, and amino acid, a major challenge remains to provide conclusive aging biomarkers.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.