Evidence map›Paper›PMID 33815817›Full record

ArticleFuture science OA2021

The histone modification H3K4me3 is altered at the

Adam R Smith, Rebecca G Smith, Ruby Macdonald, Sarah J Marzi, Joe Burrage, Claire Troakes, Safa Al-Sarraj, Jonathan Mill, Katie Lunnon

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Future science OA, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Review
  6. Review
  7. Review
  8. Review
  9. Histone Modifications in Neurological Disorders.Advances in experimental medicine and biology · 2022
    Review
  10. Epigenetics in Alzheimer's Disease.Frontiers in aging neuroscience · 2022
    Review
  11. Histone Methylation Regulation in Neurodegenerative Disorders.International journal of molecular sciences · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Adam R SmithUniversity of Exeter Medical School, University of Exeter, Exeter EX2 5DW, UK.ORCID https://orcid.org/0000-0001-6495-2711
Rebecca G SmithUniversity of Exeter Medical School, University of Exeter, Exeter EX2 5DW, UK.
Ruby MacdonaldUniversity of Exeter Medical School, University of Exeter, Exeter EX2 5DW, UK.
Sarah J MarziThe Blizard Institute, Queen Mary University of London, London E1 2AT, UK.
Joe BurrageUniversity of Exeter Medical School, University of Exeter, Exeter EX2 5DW, UK.
Claire TroakesInstitute of Psychiatry, Psychology & Neuroscience, King's College London, London SE5 8AF, UK.
Safa Al-SarrajInstitute of Psychiatry, Psychology & Neuroscience, King's College London, London SE5 8AF, UK.
Jonathan MillUniversity of Exeter Medical School, University of Exeter, Exeter EX2 5DW, UK.
Katie LunnonUniversity of Exeter Medical School, University of Exeter, Exeter EX2 5DW, UK.ORCID https://orcid.org/0000-0001-7570-6065
University of Exeter · GBKing's College London · GBQueen Mary University of London · GB

Funding

A multi-faceted approach to epigenomic profiling in Alzheimer's disorderR01AG036039 · NIA · KING'S COLLEGE LONDON · PI MILL, JONATHAN · 2009 to 2012
$1.7M
Medical Research Council MR/L016397/1Medical Research Council MR/N027973/1NIA NIH HHS R01 AG036039
6 · The paper itself

Abstract

Several epigenome-wide association studies of DNA methylation have highlighted altered DNA methylation in the

Indexed as

Alzheimer's diseaseANK1brainchromatin modificationsDNA methylationEpigeneticsH3K27me3H3K4me3histone modifications

Identifiers

PMID33815817
PMCPMC8015672
OpenAlexW3126440369

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.