ArticleTherapeutic advances in infectious disease
Increased mortality associated with uncontrolled diabetes mellitus in patients with pulmonary cryptococcosis: a single US cohort study.
Article in Therapeutic advances in infectious disease. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 16 citations in OpenAlex.
- Uncovering the impact of co-infections on disease severity and mortality in pulmonary cryptococcosis.BMC infectious diseases · 2026Article
- Species-Dependent Antifungal Profiles of Chitosan and Sulphated Polysaccharide-Rich Extract fromMarine drugs · 2026Article
- Evaluating the diagnostic efficacy of metagenomic next-generation sequencing in bronchoalveolar lavage fluid for pulmonary cryptococcosis with different clinical and imaging characteristics.BMC infectious diseases · 2025Article
- A nomogram to predict cryptococcal meningitis in patients with pulmonary cryptococcosis.Heliyon · 2024Article
- Article
- Cryptococcal Meningoencephalitis in Phenotypically Normal Patients.Pathogens (Basel, Switzerland) · 2023Review
- Diabetes Mellitus Type 2 as a Risk Factor and Outcome Modifier for Cryptococcosis in HIV Negative, Non-transplant Patients, a Propensity Score Match Analysis.Current microbiology · 2023Article
- Clinical Characteristics and Factors Associated with In-Hospital Mortality in 66 755 Patients Hospitalized Due to Diabetes in Poland, January to December 2019.Medical science monitor : international medical journal of experimental and clinical research · 2022Article
- Disseminated Cryptococcal Infection of the Lumbar Spine in an Immunocompetent Man.Infection and drug resistance · 2022Article
- Comprehensive Analysis and Risk Identification of Pulmonary Cryptococcosis in Non-HIV Patients.Journal of fungi (Basel, Switzerland) · 2021Article
- Epidemiological trends and clinical outcomes of cryptococcosis in a medically insured population in the United States: a claims-based analysis from 2017 to 2019.Therapeutic advances in infectious diseaseArticle
- Cryptococcosis in a patient with multiple myeloma receiving pomalidomide: a case report and literature review.Therapeutic advances in infectious diseaseArticle
Corrections and comments
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Authors and funding
15 authors at 8 institutions in 6 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDiabetes mellitus is an established risk factor for bacterial infections, but its role in cryptococcosis is unclear. The study aimed to determine whether uncontrolled diabetes (HbA1c >7%) was an independent risk factor for mortality in cryptococcosis.
methodsA retrospective case-control study partially matched by age and gender was performed in patients tested for
resultsWe identified 96 cases of cryptococcosis and 125 controls. Among cases, cryptococcal meningitis (49.0%) and pneumonia (36.5%) constituted most infections. Cases with pulmonary cryptococcosis with uncontrolled diabetes had a higher mortality at 10 weeks (50%
conclusionUncontrolled diabetes is associated with worse outcomes in pulmonary cryptococcosis, including a 4-fold and 6-fold increased odds of death at 10 weeks and 1 year, respectively. Glucose control interventions should be explored to improve clinical outcomes in patients with pulmonary cryptococcosis.
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