Evidence map›Paper›PMID 33815695›Full record

ArticleJournal of extracellular vesicles2021

Natalie J Bitto, Lesley Cheng, Ella L Johnston, Rishi Pathirana, Thanh Kha Phan, Ivan K H Poon, Neil M O'Brien-Simpson, Andrew F Hill, Timothy P Stinear, Maria Kaparakis-Liaskos

Open access · goldAbstract read
In one paragraph

Article in Journal of extracellular vesicles, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 120 papers.

0numbers the graph read from it
0cells of the map it votes in
120citing papers in PubMed
17.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

120 citing papers in PubMed, 173 citations in OpenAlex.

  1. Gut microbes · 2026
    Article
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  6. Review
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Review
  13. Article
  14. Extracellular vesicles as indicators of environmental stress response inExtracellular vesicles and circulating nucleic acids · 2026
    Article
  15. Review
  16. Article
  17. Review
  18. ACS omega · 2025
    Article
  19. Article
  20. Article

60 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Natalie J BittoDepartment of Physiology Anatomy and Microbiology La Trobe University Melbourne Victoria 3086 Australia.ORCID 0000-0003-3533-9824
Lesley ChengResearch Centre for Extracellular Vesicles School of Molecular Sciences La Trobe University Melbourne Victoria 3086 Australia.
Ella L JohnstonDepartment of Physiology Anatomy and Microbiology La Trobe University Melbourne Victoria 3086 Australia.ORCID 0000-0003-2880-5719
Rishi PathiranaDepartment of Physiology Anatomy and Microbiology La Trobe University Melbourne Victoria 3086 Australia.
Thanh Kha PhanResearch Centre for Extracellular Vesicles School of Molecular Sciences La Trobe University Melbourne Victoria 3086 Australia.
Ivan K H PoonResearch Centre for Extracellular Vesicles School of Molecular Sciences La Trobe University Melbourne Victoria 3086 Australia.
Neil M O'Brien-SimpsonCentre for Oral Health Research Melbourne Dental School Bio21 Institute The University of Melbourne Parkville Victoria 3010 Australia.
Andrew F HillResearch Centre for Extracellular Vesicles School of Molecular Sciences La Trobe University Melbourne Victoria 3086 Australia.ORCID 0000-0001-5581-2354
Timothy P StinearDepartment of Microbiology and Immunology Doherty Institute University of Melbourne Parkville Victoria 3010 Australia.
Maria Kaparakis-LiaskosDepartment of Physiology Anatomy and Microbiology La Trobe University Melbourne Victoria 3086 Australia.ORCID 0000-0002-8964-4456
La Trobe University · AUThe University of Melbourne · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gram-positive bacteria ubiquitously produce membrane vesicles (MVs), and although they contribute to biological functions, our knowledge regarding their composition and immunogenicity remains limited. Here we examine the morphology, contents and immunostimulatory functions of MVs produced by three

Indexed as

A549 CellsAutophagyCell WallCytokinesDNAExtracellular VesiclesHEK293 CellsHumansImmunity, InnatePeptidoglycanReceptors, ImmunologicRNAStaphylococcal InfectionsStaphylococcus aureusToll-Like Receptor 2CytokinesDNAPeptidoglycanReceptors, ImmunologicRNATLR2 protein, humanToll-Like Receptor 2autophagybacterial membrane vesiclesbacterial pathogenesisDNAinnate immunityNOD2peptidoglycanRNAStaphylococcus aureusTLRs

Identifiers

PMID33815695
PMCPMC8015888
OpenAlexW3147410553

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.