Evidence map›Paper›PMID 33815655›Full record

ArticleOxidative medicine and cellular longevity2021

Effect of Different Exercise Intensities on Hepatocyte Apoptosis in HFD-Induced NAFLD in Rats: The Possible Role of Endoplasmic Reticulum Stress through the Regulation of the IRE1/JNK and eIF2

Ling Ruan, Fanghui Li, Shoubang Li, Mingjun Zhang, Feng Wang, Xianli Lv, Qin Liu

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oxidative medicine and cellular longevity, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 18 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Ling RuanDepartment of Physical Education, Xi'an Shiyou University, Xi'an, Shaanxi, China.ORCID https://orcid.org/0000-0002-9241-3528
Fanghui LiSchool of Sports Sciences, Nanjing Normal University, Nanjing, Jiangsu, China.
Shoubang LiDepartment of Physical Education, Xi'an Shiyou University, Xi'an, Shaanxi, China.
Mingjun ZhangSchool of Sports and Health Sciences, Xi'an Physical Education University, Xi'an, Shaanxi, China.
Feng WangAnkang Traditional Chinese Medicine, Ankang, Shaanxi, China.
Xianli LvSchool of Physical Education, Ankang University, Ankang, Shaanxi, China.
Qin LiuSchool of Physical Education, Ankang University, Ankang, Shaanxi, China.
Ankang University · CNXi'an Shiyou University · CNNanjing Normal University · CNXi'an Physical Education University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo investigate the impact of different-intensity exercise on lipid metabolism, oxidative stress, hepatocyte injury, and apoptosis and the related protein expression of endoplasmic reticulum stress on nonalcoholic fatty liver disease rats.

method50 male Sprague-Dawley rats, 2 months old, were randomly divided into the normal control (CON) group, high-fat diet (HFD) group, low-intensity exercise (LIE) group, moderate-intensity exercise (MIE) group, and incremental-intensity exercise (IIE) group. Blood lipids were tested by the automatic biochemical analyzer. The changes in liver tissues were observed by hematoxylin-eosin staining (HE). The protein expression of Bax and Bcl-2 was detected by the immunohistochemical method. The apoptosis of hepatocytes was detected by the TUNEL method. The protein expression of GRP78, Caspase-3, IRE1, p-IRE1, JNK1, CHOP, PERK, eIF2

resultsOur study showed that compared with the HFD group, TG, TC, FFA, and LDL-c were reduced in all exercise groups. The different exercise intensities could reduce the protein expression of ATF4, Bax, and hepatocyte apoptosis. Meanwhile, the antioxidant function and Bcl-2 were increased. However, the moderate-intensity exercise demonstrated more effect on improving the antioxidant capacity and inhibiting hepatocyte apoptosis. Compared with the HFD group, Caspase-3 and JNK were significantly decreased in all exercise groups (

conclusionExercise at different intensities improved blood lipid and hepatic injury in NAFLD rats. However, the body weight of the rats in each exercise group was not significantly different. Moderate-intensity exercise demonstrated more effect on improving the antioxidant ability and inhibiting hepatocyte apoptosis. The possible mechanism depends on the regulation of endoplasmic reticulum stress signaling pathways IRE1/JNK and eIF2

Indexed as

ApoptosisEndoplasmic Reticulum StressMAP Kinase Signaling SystemPhysical Conditioning, AnimalAnimalsbcl-2-Associated X ProteinBody WeightCaspase 3Diet, High-FateIF-2 KinaseEndoplasmic Reticulum Chaperone BiPEukaryotic Initiation Factor-2Feeding BehaviorHeat-Shock ProteinsHepatocytesLipid Metabolismbcl-2-Associated X ProteinCaspase 3eIF-2 KinaseEndoplasmic Reticulum Chaperone BiPErn2 protein, ratEukaryotic Initiation Factor-2Heat-Shock ProteinsMembrane ProteinsProtein Serine-Threonine KinasesTranscription Factor CHOP

Identifiers

PMID33815655
PMCPMC7987464
OpenAlexW3138009108

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.