Evidence map›Paper›PMID 33815413›Full record

ArticleFrontiers in immunology2021

Subunit Vaccines Using TLR Triagonist Combination Adjuvants Provide Protection Against

Alycia P Fratzke, Sharon Jan, Jiin Felgner, Li Liang, Rie Nakajima, Algis Jasinskas, Saikat Manna, Fnu N Nihesh, Sampa Maiti, Tyler J Albin and 5 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
5.9field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 41 citations in OpenAlex.

  1. Review
  2. The Squalene Oil-in-Water Nanoemulsion Vaccine Carrier AddaVax Potentiates TLR-Induced B-Cell Responses.Cytometry. Part A : the journal of the International Society for Analytical Cytology · 2026
    Article
  3. Review
  4. Review
  5. Review
  6. Molecular mechanisms ofInfection and immunity · 2024
    Article
  7. Review
  8. Article
  9. Review
  10. Review
  11. Article
  12. Article
  13. Article
  14. Preclinical Animal Models for Q Fever Vaccine Development.Frontiers in cellular and infection microbiology · 2022
    Review
  15. Review
  16. Soluble antigens derived fromCell reports. Medicine · 2021
    Article
  17. Recent Advances on the Innate Immune Response toFrontiers in cellular and infection microbiology · 2021
    Review
  18. Frontiers in immunology · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 1 country.

Alycia P FratzkeDepartment of Microbial Pathogenesis and Immunology, Texas A&M Health Science Center, Bryan, TX, United States.
Sharon JanVaccine Research and Development Center, Department of Physiology and Biophysics, University of California, Irvine, Irvine, CA, United States.
Jiin FelgnerVaccine Research and Development Center, Department of Physiology and Biophysics, University of California, Irvine, Irvine, CA, United States.
Li LiangVaccine Research and Development Center, Department of Physiology and Biophysics, University of California, Irvine, Irvine, CA, United States.
Rie NakajimaVaccine Research and Development Center, Department of Physiology and Biophysics, University of California, Irvine, Irvine, CA, United States.
Algis JasinskasVaccine Research and Development Center, Department of Physiology and Biophysics, University of California, Irvine, Irvine, CA, United States.
Saikat MannaPritzker School of Molecular Engineering, University of Chicago, Chicago, IL, United States.
Fnu N NiheshPritzker School of Molecular Engineering, University of Chicago, Chicago, IL, United States.
Sampa MaitiPritzker School of Molecular Engineering, University of Chicago, Chicago, IL, United States.
Tyler J AlbinDepartment of Chemistry, University of California, Irvine, Irvine, CA, United States.
Aaron P Esser-KahnPritzker School of Molecular Engineering, University of Chicago, Chicago, IL, United States.
D Huw DaviesVaccine Research and Development Center, Department of Physiology and Biophysics, University of California, Irvine, Irvine, CA, United States.
James E SamuelDepartment of Microbial Pathogenesis and Immunology, Texas A&M Health Science Center, Bryan, TX, United States.
Philip L FelgnerVaccine Research and Development Center, Department of Physiology and Biophysics, University of California, Irvine, Irvine, CA, United States.
Anthony E GregoryDepartment of Microbial Pathogenesis and Immunology, Texas A&M Health Science Center, Bryan, TX, United States.
University of California, Irvine · USUniversity of Chicago · USTexas A&M Health Science Center · US

Funding

Comparative Biomedical Research Training for VeterinariansT32OD011083 · OD · TEXAS A&M AGRILIFE RESEARCH · PI ALBERT MULENGA · 2012 to 2026
$4.8M
NIH HHS T32 OD011083
6 · The paper itself

Abstract

Q fever is caused by the obligate intracellular bacterium,

Indexed as

Adjuvants, ImmunologicAnimalsAntigens, BacterialBacterial ProteinsBacterial VaccinesCoxiella burnetiiDisease Models, AnimalGuinea PigsHumansImmunogenicity, VaccineQ FeverRecombinant ProteinsToll-Like ReceptorsVaccines, SubunitVaccines, SyntheticAdjuvants, ImmunologicAntigens, BacterialBacterial ProteinsBacterial VaccinesRecombinant ProteinsToll-Like ReceptorsVaccines, SubunitVaccines, SyntheticCoxiella burnetiiguinea pig modelhypersensitivityTLR agonisttriagonistvaccine

Identifiers

PMID33815413
PMCPMC8010241
OpenAlexW3138131556

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.