Evidence map›Paper›PMID 33815412›Full record

ArticleFrontiers in immunology2021

Humanized Mice Exhibit Exacerbated Abscess Formation and Osteolysis During the Establishment of Implant-Associated

Gowrishankar Muthukrishnan, Alexandra Wallimann, Javier Rangel-Moreno, Karen L de Mesy Bentley, Maria Hildebrand, Karen Mys, H Mark Kenney, Eric T Sumrall, John L Daiss, Stephan Zeiter and 3 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
4.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 26 citations in OpenAlex.

  1. Review
  2. Osteomyelitis.Nature reviews. Disease primers · 2026
    Review
  3. Review
  4. Article
  5. Article
  6. Article
  7. Immune Checkpoint Molecules as Biomarkers ofbioRxiv : the preprint server for biology · 2024
    Article
  8. Humanized Mouse Models of Bacterial Infections.Antibiotics (Basel, Switzerland) · 2024
    Review
  9. The 2023 Orthopaedic Research Society's International Consensus Meeting on musculoskeletal infection: Summary from the host immunity section.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2024
    Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Fracture-related infection.Nature reviews. Disease primers · 2022
    Review
  15. Article
  16. Review
  17. Review
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 2 countries.

Gowrishankar MuthukrishnanCenter for Musculoskeletal Research, Department of Orthopaedics and Rehabilitation, University of Rochester Medical Center, Rochester, NY, United States.
Alexandra WallimannAO Research Institute Davos, Davos, Switzerland.
Javier Rangel-MorenoDivision of Allergy, Immunology and Rheumatology, Department of Medicine, University of Rochester Medical Center, Rochester, NY, United States.
Karen L de Mesy BentleyCenter for Musculoskeletal Research, Department of Orthopaedics and Rehabilitation, University of Rochester Medical Center, Rochester, NY, United States.
Maria HildebrandAO Research Institute Davos, Davos, Switzerland.
Karen MysAO Research Institute Davos, Davos, Switzerland.
H Mark KenneyCenter for Musculoskeletal Research, Department of Orthopaedics and Rehabilitation, University of Rochester Medical Center, Rochester, NY, United States.
Eric T SumrallAO Research Institute Davos, Davos, Switzerland.
John L DaissCenter for Musculoskeletal Research, Department of Orthopaedics and Rehabilitation, University of Rochester Medical Center, Rochester, NY, United States.
Stephan ZeiterAO Research Institute Davos, Davos, Switzerland.
R Geoff RichardsAO Research Institute Davos, Davos, Switzerland.
Edward M SchwarzCenter for Musculoskeletal Research, Department of Orthopaedics and Rehabilitation, University of Rochester Medical Center, Rochester, NY, United States.
T Fintan MoriartyAO Research Institute Davos, Davos, Switzerland.
AO Foundation · CHUniversity of Rochester Medical Center · USUniversity of Zurich · CH

Funding

Project 2: Defining the Protective vs. Susceptible Immune Proteome of S. aureus OsteomyelitisP50AR072000 · NIAMS · UNIVERSITY OF ROCHESTER · PI Edward M. Schwarz · 2017 to 2026
$13.6M
ROLE OF INDUCIBLE BRONCHUS ASSOCIATED LYMPHOID TISSUE IN LATENT TUBERCULOSISR01AI111914 · NIAID · WASHINGTON UNIVERSITY · PI KAUSHAL, DEEPAK, KHADER, SHABAANA A. · 2015 to 2025
$11.1M
Rochester Resource-Based Center for Bone, Muscle and Orthopaedic Research (ROCSTARR) (Overall Application)P30AR069655 · NIAMS · UNIVERSITY OF ROCHESTER · PI Edward M. Schwarz · 2016 to 2026
$7.8M
Training in Musculoskeletal Science: Comprehensive Training in Pain StudiesT32AR076950 · NIAMS · UNIVERSITY OF ROCHESTER · PI Hani A Awad, Laura M Calvi · 2020 to 2026
$1.7M
NIAID NIH HHS R01 AI111914NIAMS NIH HHS P30 AR069655NIAMS NIH HHS P50 AR072000NIAMS NIH HHS T32 AR076950
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AbscessAnimalsDisease Models, AnimalFemaleHematopoietic Stem Cell TransplantationHumansMiceOsteolysisOsteomyelitisProsthesis-Related InfectionsStaphylococcal InfectionsStaphylococcus aureusTransplantation Chimerabone infectionhumanized miceosteolysisstaphylococcal abscess communitiesStaphylococcus aureusT cells

Identifiers

PMID33815412
PMCPMC8012494
OpenAlexW3137609608

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.