Evidence map›Paper›PMID 33815408›Full record

Observational studyFrontiers in immunology2021

Transcriptome and IgH Repertoire Analyses Show That CD11c

Robert W Maul, Michelle D Catalina, Varsha Kumar, Prathyusha Bachali, Amrie C Grammer, Shu Wang, William Yang, Sarfaraz Hasni, Rachel Ettinger, Peter E Lipsky and 1 more

Open access · goldAbstract readObservational Study
In one paragraph

Observational study in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 33 citations in OpenAlex.

  1. Article
  2. Article
  3. Pathogenic Role of Cytokines in Rheumatoid Arthritis.Journal of clinical medicine · 2025
    Review
  4. CD21Frontiers in immunology · 2025
    Article
  5. CD11cNeurology(R) neuroimmunology & neuroinflammation · 2024
    Observational
  6. B-Cell Receptor Repertoire: Recent Advances in Autoimmune Diseases.Clinical reviews in allergy & immunology · 2024
    Review
  7. Immune dysregulation in immunoglobulin G4-related disease.The Japanese dental science review · 2023
    Review
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. CD11cFrontiers in immunology · 2022
    Article
  17. Review
  18. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 1 country.

Robert W MaulLaboratory of Molecular Biology and Immunology, National Institute on Aging, National Institutes of Health, Baltimore, MD, United States.
Michelle D CatalinaAMPEL BioSolutions LLC, Charlottesville, VA, United States.
Varsha KumarResearch and Early Development, Respiratory and Immunology, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, MD, United States.
Prathyusha BachaliAMPEL BioSolutions LLC, Charlottesville, VA, United States.
Amrie C GrammerAMPEL BioSolutions LLC, Charlottesville, VA, United States.
Shu WangViela Bio, Gaithersburg, MD, United States.
William YangLaboratory of Molecular Biology and Immunology, National Institute on Aging, National Institutes of Health, Baltimore, MD, United States.
Sarfaraz HasniLupus Clinical Research Program, Office of the Clinical Director, National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, MD, United States.
Rachel EttingerViela Bio, Gaithersburg, MD, United States.
Peter E LipskyAMPEL BioSolutions LLC, Charlottesville, VA, United States.
Patricia J GearhartLaboratory of Molecular Biology and Immunology, National Institute on Aging, National Institutes of Health, Baltimore, MD, United States.
Ampel BioSolutions (United States) · USNational Institutes of Health · USAstraZeneca (United States) · USNational Institute of Arthritis and Musculoskeletal and Skin Diseases · USNational Institute on Aging · US

Funding

Protein Interactions in Antibody DiversityZIAAG000732 · NIA · NATIONAL INSTITUTE ON AGING · PI GEARHART, PATRICIA J · 2009 to 2025
$10.7M
Protein Interactions in Antibody DiversityZ01AG000732 · NIA · NATIONAL INSTITUTE ON AGING · PI GEARHART, PATRICIA J · 1996 to 2008
$974k
Intramural NIH HHS Z01 AG000732
6 · The paper itself

Abstract

A distinct B cell population marked by elevated CD11c expression is found in patients with systemic lupus erythematosus (SLE). Cells with a similar phenotype have been described during chronic infection, but variable gating strategies and nomenclature have led to uncertainty of their relationship to each other. We isolated CD11c

Indexed as

AdultAgedAnimalsB-Lymphocyte SubsetsCD11c AntigenComputational BiologyDatasets as TopicFemaleGene Expression ProfilingGerminal CenterHumansImmunoglobulin Heavy ChainsInfectionsLupus Erythematosus, SystemicMiceMiddle AgedCD11c AntigenImmunoglobulin Heavy ChainsautoimmunityB cellsB cell transcriptomeCD11cIGH repertoireSLE

Identifiers

PMID33815408
PMCPMC8017342
OpenAlexW3138236774

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.