Evidence map›Paper›PMID 33815385›Full record

ArticleFrontiers in immunology2021

Enhanced Glycolysis Is Required for Antileishmanial Functions of Neutrophils Upon Infection With

Mareike Ohms, Carolina Ferreira, Hauke Busch, Inken Wohlers, Ana Cristina Guerra de Souza, Ricardo Silvestre, Tamás Laskay

Abstract read
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed.

  1. Review
  2. Article
  3. Frontiers in immunology · 2026
    Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Activation induces shift in nutrient utilization that differentially impacts cell functions in human neutrophils.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  9. Article
  10. The intersection of hostMicrobiology and molecular biology reviews : MMBR · 2024
    Review
  11. EXCLI journal · 2024
    Article
  12. Article
  13. LeishMANIAdb: a comparative resource for Leishmania proteins.Database : the journal of biological databases and curation · 2023
    Article
  14. Article
  15. Article
  16. Frontiers in immunology · 2023
    Article
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Mareike OhmsDepartment of Infectious Diseases and Microbiology, University of Lübeck, Lübeck, Germany.
Carolina FerreiraLife and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal.
Hauke BuschMedical Systems Biology Division, Lübeck Institute of Experimental Dermatology and Institute for Cardiogenetics, University of Lübeck, Lübeck, Germany.
Inken WohlersMedical Systems Biology Division, Lübeck Institute of Experimental Dermatology and Institute for Cardiogenetics, University of Lübeck, Lübeck, Germany.
Ana Cristina Guerra de SouzaDepartment of Cell Technology, Fraunhofer Research Institution for Marine Biotechnology and Cell Technology (EMB), Lübeck, Germany.
Ricardo SilvestreLife and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal.
Tamás LaskayDepartment of Infectious Diseases and Microbiology, University of Lübeck, Lübeck, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Visceral leishmaniasis (VL) is a fatal parasitic disease if untreated. Treatment options of VL diminish due to emerging drug resistance. Although the principal host cells for the multiplication of

Indexed as

AnimalsCells, CulturedDeoxyglucoseGlucoseGlycolysisHumansLeishmania donovaniLeishmaniasis, VisceralMiceMice, Inbred C57BLNeutrophilsOxidative PhosphorylationParasite LoadReactive Oxygen SpeciesRespiratory BurstDeoxyglucoseGlucoseReactive Oxygen Species2-deoxyglucoseglucose metabolismglycolysis (glycolytic pathway)host-directed therapy (HDT)leishmanianeutrophilsoxidative phosphorylation (OXPHOS)transcriptome (RNA-seq)

Identifiers

PMID33815385
PMCPMC8017142

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.