Evidence map›Paper›PMID 33815354›Full record

ArticleFrontiers in immunology2021

Complex Interplay Between MAZR and Runx3 Regulates the Generation of Cytotoxic T Lymphocyte and Memory T Cells.

Alexandra Franziska Gülich, Ramona Rica, Caroline Tizian, Csilla Viczenczova, Kseniya Khamina, Thomas Faux, Daniela Hainberger, Thomas Penz, Remy Bosselut, Christoph Bock and 5 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.5field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 10 citations in OpenAlex.

  1. Probing transcription factor subsets in gene regulatory networks.Algorithms for molecular biology : AMB · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 6 institutions in 3 countries.

Alexandra Franziska GülichDivision of Immunobiology, Institute of Immunology, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.
Ramona RicaDivision of Immunobiology, Institute of Immunology, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.
Caroline TizianDivision of Immunobiology, Institute of Immunology, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.
Csilla ViczenczovaCeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.
Kseniya KhaminaCeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.
Thomas FauxTurku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland.
Daniela HainbergerDivision of Immunobiology, Institute of Immunology, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.
Thomas PenzCeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.
Remy BosselutLaboratory of Immune Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, United States.
Christoph BockCeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.
Asta LaihoTurku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland.
Laura L EloTurku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland.
Andreas BergthalerCeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.
Wilfried EllmeierDivision of Immunobiology, Institute of Immunology, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.
Shinya SakaguchiDivision of Immunobiology, Institute of Immunology, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.
Medical University of Vienna · ATAustrian Academy of Sciences · ATCeMM Research Center for Molecular Medicine · ATTurku Centre for Computer Science · FICenter for Cancer Research · USUniversity of Turku · FI

Funding

Genetic Analysis of T-cell DifferentiationZIABC010671 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI BOSSELUT, REMY · 2009 to 2025
$34.3M
Austrian Science Fund FWF DOC 32Austrian Science Fund FWF P 23669Austrian Science Fund FWF P 23991Austrian Science Fund FWF P 25360Austrian Science Fund FWF P 27747Austrian Science Fund FWF P 29790Austrian Science Fund FWF P 30047European Research Council 677943
6 · The paper itself

Abstract

The BTB zinc finger transcription factor MAZR (also known as PATZ1) controls, partially in synergy with the transcription factor Runx3, the development of CD8 lineage T cells. Here we explored the role of MAZR as well as combined activities of MAZR/Runx3 during cytotoxic T lymphocyte (CTL) and memory CD8

Indexed as

AnimalsCD8-Positive T-LymphocytesCell DifferentiationCore Binding Factor Alpha 3 SubunitGene Expression RegulationHost-Pathogen InteractionsImmunologic MemoryLymphocyte ActivationLymphocytic ChoriomeningitisLymphocytic choriomeningitis virusMiceMice, KnockoutMice, TransgenicNeoplasm ProteinsRepressor ProteinsT-Lymphocytes, CytotoxicCore Binding Factor Alpha 3 SubunitNeoplasm ProteinsRepressor ProteinsRunx3 protein, mouseZfp278 protein, mousecytotoxic T lymphocyteLCMVMAZR/PATZ1memory T cellRunx3transcriptional control

Identifiers

PMID33815354
PMCPMC8010151
OpenAlexW3137154626

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.