Evidence map›Paper›PMID 33815346›Full record

ArticleFrontiers in microbiology2021

Learning From Mistakes: The Role of Phages in Pandemics.

Ahlam Alsaadi, Beatriz Beamud, Maheswaran Easwaran, Fatma Abdelrahman, Ayman El-Shibiny, Majed F Alghoribi, Pilar Domingo-Calap

Open access · goldAbstract read
In one paragraph

Article in Frontiers in microbiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
3.2field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 20 citations in OpenAlex.

  1. Plausible mechanism of drug resistance and side-effects of COVID-19 therapeutics: a bottleneck for its eradication.Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences · 2024
    Review
  2. Impact of phage predation onRNA biology · 2023
    Article
  3. Article
  4. A Perspective on Studies of Phage DNA Packaging Dynamics.International journal of molecular sciences · 2022
    Article
  5. Article
  6. Review
  7. Review
  8. Article
  9. Article
  10. Phage Therapy in Livestock and Companion Animals.Antibiotics (Basel, Switzerland) · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 4 countries.

Ahlam AlsaadiDepartment of Veterinary and Animal Sciences, University of Copenhagen, Frederiksberg, Denmark.
Beatriz BeamudInstitute for Integrative Systems Biology, I2SysBio, Universitat de València-CSIC, Paterna, Spain.
Maheswaran EaswaranDepartment of Biomedical Engineering, Sethu Institute of Technology, Rajapalayam, India.
Fatma AbdelrahmanCenter for Microbiology and Phage Therapy, Biomedical Sciences, Zewail City of Science and Technology, Giza, Egypt.
Ayman El-ShibinyCenter for Microbiology and Phage Therapy, Biomedical Sciences, Zewail City of Science and Technology, Giza, Egypt.
Majed F AlghoribiInfectious Diseases Research Department, King Abdullah International Medical Research Center, Riyadh, Saudi Arabia.
Pilar Domingo-CalapInstitute for Integrative Systems Biology, I2SysBio, Universitat de València-CSIC, Paterna, Spain.
Zewail City of Science and Technology · EGInstitute for Integrative Systems Biology · ESKing Saud bin Abdulaziz University for Health Sciences · SAUniversitat de València · ESUniversity of Copenhagen · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The misuse of antibiotics is leading to the emergence of multidrug-resistant (MDR) bacteria, and in the absence of available treatments, this has become a major global threat. In the middle of the recent severe acute respiratory coronavirus 2 (SARS-CoV-2) pandemic, which has challenged the whole world, the emergence of MDR bacteria is increasing due to prophylactic administration of antibiotics to intensive care unit patients to prevent secondary bacterial infections. This is just an example underscoring the need to seek alternative treatments against MDR bacteria. To this end, phage therapy has been proposed as a promising tool. However, further research in the field is mandatory to assure safety protocols and to develop appropriate regulations for its use in clinics. This requires investing more in such non-conventional or alternative therapeutic approaches, to develop new treatment regimens capable of reducing the emergence of MDR and preventing future global public health concerns that could lead to incalculable human and economic losses.

Indexed as

antibiotic resistanceemergent pathogenmultidrug-resistant bacteriaphage therapypublic health

Identifiers

PMID33815346
PMCPMC8010138
OpenAlexW3136880986

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.