Evidence map›Paper›PMID 33815287›Full record

ArticleFrontiers in endocrinology2021

The Vbeta13 T Cell Receptor Monoclonal Antibody Reduces Hyaluronan and CD68+, CD3+, and CD8+ Cell Infiltrations to Delay Diabetes in Congenic BB DR

Marika Bogdani, Linda Faxius, Malin Fex, Anita Ramelius, Anya Wernersson, John P Mordes, Elizabeth P Blankenhorn, Åke Lernmark

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in endocrinology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 61% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Quantitative temporal analysis of pancreatic islet T lymphocyte and macrophage infiltration heralded by serum IgE in congenic BioBreeding (BB) Gimap5Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2025
    Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 2 countries.

Marika BogdaniMatrix Biology Program, Benaroya Research Institute at Virginia Mason, Seattle, WA, United States.
Linda FaxiusDepartment of Clinical Sciences, Lund University Clinical Research Center (CRC), Skåne University Hospital, Malmö, Sweden.
Malin FexDepartment of Clinical Sciences, Lund University Clinical Research Center (CRC), Skåne University Hospital, Malmö, Sweden.
Anita RameliusDepartment of Clinical Sciences, Lund University Clinical Research Center (CRC), Skåne University Hospital, Malmö, Sweden.
Anya WernerssonDepartment of Clinical Sciences, Lund University Clinical Research Center (CRC), Skåne University Hospital, Malmö, Sweden.
John P MordesDepartment of Medicine, University of Massachusetts, Worcester, MA, United States.
Elizabeth P BlankenhornDepartment of Microbiology & Immunology, Drexel University College of Medicine, Philadelphia, PA, United States.
Åke LernmarkDepartment of Clinical Sciences, Lund University Clinical Research Center (CRC), Skåne University Hospital, Malmö, Sweden.
Skåne University Hospital · SELund University · SEBenaroya Research InstituteDrexel University · USUniversity of Massachusetts Chan Medical School · US

Funding

Defining the role of altered cytokine signaling pathways on autoimmunityU01AI101990 · NIAID · BENAROYA RESEARCH INST AT VIRGINIA MASON · PI BUCKNER, JANE HOYT · 2012 to 2016
$12.1M
NIAID NIH HHS U01 AI101990
6 · The paper itself

Abstract

The depleting Vβ13a T cell receptor monoclonal antibody (mAb) 17D5 prevents both induced and spontaneous autoimmune diabetes in BB rats. Here it was tested in congenic DR

Indexed as

AnimalsAntibodies, MonoclonalAntigens, CDAntigens, Differentiation, MyelomonocyticBlood GlucoseCD3 ComplexCD68 MoleculeCD8-Positive T-LymphocytesDiabetes Mellitus, ExperimentalHyaluronic AcidInsulin-Secreting CellsMacrophagesPolymorphism, Single NucleotideRatsRats, Inbred BBReceptors, Antigen, T-CellAntibodies, MonoclonalAntigens, CDAntigens, Differentiation, MyelomonocyticBlood GlucoseCD3 ComplexCD68 MoleculeCD68 protein, ratHyaluronic AcidReceptors, Antigen, T-Cellautoimmune diabetesBB rathyaluronaninsulitispancreatic isletsT-cell receptor

Identifiers

PMID33815287
PMCPMC8010654
OpenAlexW3136815944

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.