Evidence map›Paper›PMID 33815250›Full record

ArticleFrontiers in neurology2021

Rapid Intervention of Chlorpromazine and Promethazine for Hibernation-Like Effect in Stroke: Rationale, Design, and Protocol for a Prospective Randomized Controlled Trial.

Shuyu Lv, Wenbo Zhao, Gary B Rajah, Chaitu Dandu, Lipeng Cai, Zhe Cheng, Honglian Duan, Qingqing Dai, Xiaokun Geng, Yuchuan Ding

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in neurology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06663631 (The Safety and effiCacy of HIbernation-Like Therapy Combining recanaLization in Ischemic Stroke), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 97% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06663631 phase1recruitingnot on this mapstarted 2024, after this paper: background citation

The Safety and effiCacy of HIbernation-Like Therapy Combining recanaLization in Ischemic Stroke: a Phase 1, Dose-escalation Study

TypeinterventionalSponsorCapital Medical UniversityRan2024 to 2025Enrolled32ConditionsAcute Ischemic StrokeArmschlorpromazine and promethazine, Placebo group, endovascular thrombectomy, rt-PA
3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 2 countries.

Shuyu LvLuhe Institute of Neuroscience, Capital Medical University, Beijing, China.
Wenbo ZhaoChina-America Institute of Neuroscience, Xuanwu Hospital, Capital Medical University, Beijing, China.
Gary B RajahDepartment of Neurosurgery, Wayne State University School of Medicine, Detroit, MI, United States.
Chaitu DanduDepartment of Neurosurgery, Wayne State University School of Medicine, Detroit, MI, United States.
Lipeng CaiDepartment of Neurology, Beijing Luhe Hospital, Capital Medical University, Beijing, China.
Zhe ChengDepartment of Neurology, Beijing Luhe Hospital, Capital Medical University, Beijing, China.
Honglian DuanDepartment of Neurology, Beijing Luhe Hospital, Capital Medical University, Beijing, China.
Qingqing DaiDepartment of Neurology, Beijing Luhe Hospital, Capital Medical University, Beijing, China.
Xiaokun GengLuhe Institute of Neuroscience, Capital Medical University, Beijing, China.
Yuchuan DingDepartment of Neurosurgery, Wayne State University School of Medicine, Detroit, MI, United States.
Beijing Luhe Hospital Affiliated to Capital Medical University · CNCapital Medical University · CNJohn D. Dingell VA Medical Center · USMunson Medical Center · USWayne State University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

acute ischemic stroke (AIS)intravenous thrombolysisneuroprotectionphenothiazinert-PA

Identifiers

PMID33815250
PMCPMC8010657
OpenAlexW3136335965

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.