ArticleFrontiers in psychiatry2021
Predicting Real-World Functioning in Schizophrenia: The Relative Contributions of Neurocognition, Functional Capacity, and Negative Symptoms.
Article in Frontiers in psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.
- Exploring the Relationship between Cognitive Performance, Performance-Based Functioning, and Everyday Functioning in People with Schizophrenia: a Systematic Literature Review.Schizophrenia bulletin · 2026Pooled it
- Glutamatergic Modulators in Schizophrenia: Are We Ready to Move Beyond the Narrow Focus on Dopamine? A Potential Paradigm Shift in Psychopharmacology.Alpha psychiatry · 2026Article
- Toward Generalizable and Clinically Useful Prediction of Occupational Functioning in Schizophrenia Using a Structure-Informed Representation of Cognition.medRxiv : the preprint server for health sciences · 2026Article
- Article
- Assessing directional connections between symptoms, cognition, insight, and real-life functioning in schizophrenia: a partial ancestor graphs analysis.Frontiers in psychiatry · 2026Article
- Interrelationships of long-term changes in recovery domains among patients with schizophrenia spectrum disorders: a six-year follow-up study.BMC psychiatry · 2025Article
- Relationship between cognitive reserve (education), social cognition and negative symptoms.Schizophrenia research. Cognition · 2025Article
- Managing health in dual diagnosis: narratives from individuals with schizophrenia and diabetes.Frontiers in psychiatry · 2025Article
- Predictors of Psychosocial Functioning Among Long-stay Schizophrenia Patients in a Malaysian Mental Institution.The Malaysian journal of medical sciences : MJMS · 2024Article
- Biomarker discovery using machine learning in the psychosis spectrum.Biomarkers in neuropsychiatry · 2024Article
- Abnormal hedonic process in patients with stable schizophrenia: Relationships to negative symptoms and social functioning.Schizophrenia research. Cognition · 2024Article
- Validation of the Comprehensive and Brief International Classification of Functioning, Disability and Health Core Sets for Schizophrenia from the Perspective of Individuals Diagnosed with the Disorder: A Worldwide Study Using Focus Groups.Behavioral sciences (Basel, Switzerland) · 2024Article
- Article
- Article
- Predictors of functioning in treatment-resistant schizophrenia: the role of negative symptoms and neurocognition.Frontiers in psychiatry · 2024Article
- What factors should we modify to promote high functioning and prevent functional decline in people with schizophrenia?Frontiers in psychiatry · 2023Article
- Optimal cutoff scores of the Chinese version of 15-item negative symptom assessment that indicate prominent negative symptoms of schizophrenia.Frontiers in psychiatry · 2023Article
- Real-World Functioning in Psychiatric Outpatients: Predictive Factors.Journal of clinical medicine · 2022Article
- The Puzzle of Functional Recovery in Schizophrenia-Spectrum Disorders-Replicating a Network Analysis Study.Schizophrenia bulletin · 2022Article
- Impact of Negative Symptoms on Functioning and Quality of Life in First Psychotic Episodes of Schizophrenia.Journal of clinical medicine · 2022Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neurocognition and functional capacity are commonly reported predictors of real-world functioning in schizophrenia. However, the additional impact of negative symptoms, specifically its subdomains, i.e., diminished expression (DE) and avolition-apathy (AA), on real-world functioning remains unclear. The current study assessed 58 individuals with schizophrenia. Neurocognition was assessed with the Brief Assessment of Cognition in Schizophrenia, functional capacity with the UCSD Performance-based Skills Assessment (UPSA-B), and negative symptoms with the Negative Symptom Assessment-16. Real-world functioning was assessed with the Multnomah Community Ability Scale (MCAS) with employment status as an additional objective outcome. Hierarchical regressions and sequential logistic regressions were used to examine the associations between the variables of interest. The results show that global negative symptoms contribute substantial additional variance in predicting MCAS and employment status above and beyond the variance accounted for by neurocognition and functional capacity. In addition, both AA and DE predict the MCAS after controlling for cognition and functional capacity. Only AA accounts for additional variance in employment status beyond that by UPSA-B. In summary, negative symptoms contribute substantial additional variance in predicting both real-world functioning and employment outcomes after accounting for neurocognition and functional capacity. Our findings emphasize both DE and AA as important treatment targets in functional recovery for people with schizophrenia.
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