Evidence map›Paper›PMID 33815154›Full record

ArticleFrontiers in physiology2021

Pathophysiological Relevance of Renal Medullary Conditions on the Behaviour of Red Cells From Patients With Sickle Cell Anaemia.

David C-Y Lu, Rasiqh Wadud, Anke Hannemann, David C Rees, John N Brewin, John Stanley Gibson

Open access · goldAbstract read
In one paragraph

Article in Frontiers in physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

David C-Y LuDepartment of Veterinary Medicine, University of Cambridge, Cambridge, United Kingdom.
Rasiqh WadudDepartment of Veterinary Medicine, University of Cambridge, Cambridge, United Kingdom.
Anke HannemannDepartment of Veterinary Medicine, University of Cambridge, Cambridge, United Kingdom.
David C ReesDepartment of Paediatric Haematology, King's College Hospital, London, United Kingdom.
John N BrewinDepartment of Paediatric Haematology, King's College Hospital, London, United Kingdom.
John Stanley GibsonDepartment of Veterinary Medicine, University of Cambridge, Cambridge, United Kingdom.
University of Cambridge · GBKing's College Hospital · GB

Funding

British Heart Foundation PG/15/118/31966
6 · The paper itself

Abstract

Red cells from patients with sickle cell anaemia (SCA) contain the abnormal haemoglobin HbS. Under hypoxic conditions, HbS polymerises and causes red cell sickling, a rise in intracellular Ca

Indexed as

HbS polymerisationhypertonicityhypoxiapHphosphatidylserinerenal medullasicklingurea

Identifiers

PMID33815154
PMCPMC8017214
OpenAlexW3138592260

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.