ArticleFrontiers in physiology2021
A High Percentage of Patients Recovered From COVID-19 but Discharged With Abnormal Liver Function Tests.
Article in Frontiers in physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed.
- Histological features of liver biopsy in patients with COVID-19: a single institution experience with long term follow-up outcome.Diagnostic pathology · 2026Article
- Drug-induced liver injury as assessed by the updated Roussel Uclaf Causality Assessment Method following mild COVID-19 in a patient under anastrozole therapy-A case report.Cancer reports (Hoboken, N.J.) · 2024Article
- Influence of time factor and albuminuria on characteristics of patients with type 2 diabetes Mellitus before, during and 1 year after COVID-19 recovery.Diabetology & metabolic syndrome · 2023Article
- Expression ofFuture virology · 2023Article
- Generalisable long COVID subtypes: findings from the NIH N3C and RECOVER programmes.EBioMedicine · 2023Article
- Acute hepatitis and liver injury in hospitalized patients with COVID‑19 infection.Experimental and therapeutic medicine · 2022Article
- SARS-CoV-2 associated liver injury: a six-month follow-up analysis of liver function recovery.Medicine and pharmacy reports · 2022Article
- Generalizable Long COVID Subtypes: Findings from the NIH N3C and RECOVER Programs.medRxiv : the preprint server for health sciences · 2022Article
- Article
- Metabolic and nutritional triggers associated with increased risk of liver complications in SARS-CoV-2.World journal of hepatology · 2022Review
- The pathological mechanism of the COVID-19 convalescence and its treatment with traditional Chinese medicine.Frontiers in pharmacology · 2022Review
- 12-Month Post-Discharge Liver Function Test Abnormalities Among Patients With COVID-19: A Single-Center Prospective Cohort Study.Frontiers in cellular and infection microbiology · 2022Article
- Autoimmune sclerosing cholangitis might be triggered by SARS-CoV-2 infection in a child - a case report.Central-European journal of immunology · 2022Article
- Comparison of the clinical and radiological manifestations of male patients with COVID-19 from different ethnicities.International journal of clinical practice · 2021Article
- Abnormal Liver Tests during Hospitalization Predict Mortality in Patients with COVID-19: A Multicenter Study from South America.Canadian journal of gastroenterology & hepatology · 2021Article
- Association between ABO blood groups and their clinical indices during COVID-19 infection.Asian journal of transfusion scienceArticle
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14 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundCoronavirus disease 2019 (COVID-19) pandemic has become the most severe global health issue. Abnormal liver functions are frequently reported in these patients. However, liver function abnormality was often overlooked during COVID-19 treatment, and data regarding liver functions after cure of COVID-19 is limited. This study aimed to reveal the changes of liver function tests (LFTs) during hospitalization, and its clinical significance in patients with COVID-19.
methodsIn this retrospective, bi-center study, a total of 158 hospitalized patients diagnosed with COVID-19 in China were included from January 22nd, 2020 to February 20th, 2020. Clinical features, laboratory parameters including LFTs, and treatment data were collected and analyzed. LFTs included alanine transaminase, aspartate aminotransferase, alkaline phosphatase, gamma-glutamyl transferase, and total bilirubin. Patients were considered with abnormal LFTs when any value of these tests was higher than upper limit of normal.
resultsOf 158 patients with COVID-19, 67 (42.41%) patients had abnormal LFTs on admission and another 50 (31.65%) patients developed abnormal LFTs during hospitalization. The incidence of LFTs abnormality in severe COVID-19 cases was significantly higher than non-severe cases. All LFTs in COVID-19 patients were correlated with oxygenation index. There was no statistical difference in treatment between the patients with or without liver test abnormalities. By the time of discharge, there were still 64 (40.50%) patients with abnormal LFTs. Logistic regression analysis identified younger age, hypertension and low lymphocyte counts as independent risk factors for persistent abnormal LFTs during hospitalization.
conclusionLiver function tests abnormality was common in COVID-19 patients and was more prevalent in severe cases than in non-severe cases. A substantial percentage of patients still had abnormal LFTs by the time of discharge.
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