Evidence map›Paper›PMID 33815108›Full record

ReviewFrontiers in pharmacology2021

The Influence of Treatment of Inflammatory Arthritis During Pregnancy on the Long-Term Children's Outcome.

Cecilia Nalli, Jessica Galli, Daniele Lini, Angela Merlini, Silvia Piantoni, Maria Grazia Lazzaroni, Victoria Bitsadze, Jamilya Khizroeva, Sonia Zatti, Laura Andreoli and 5 more

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in pharmacology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

  1. Axial spondyloarthritis and breastfeeding: a prospective study.International breastfeeding journal · 2025
    Article
  2. Review
  3. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 3 countries.

Cecilia NalliRheumatology and Clinical Immunology Unit, ASST Spedali Civili and University of Brescia, Brescia, Italy.
Jessica GalliChild Neurology and Psychiatry Unit, Department of Clinical and Experimental Sciences, ASST Spedali Civili and University of Brescia, Brescia, Italy.
Daniele LiniRheumatology and Clinical Immunology Unit, ASST Spedali Civili and University of Brescia, Brescia, Italy.
Angela MerliniChild Neurology and Psychiatry Unit, Department of Clinical and Experimental Sciences, ASST Spedali Civili and University of Brescia, Brescia, Italy.
Silvia PiantoniRheumatology and Clinical Immunology Unit, ASST Spedali Civili and University of Brescia, Brescia, Italy.
Maria Grazia LazzaroniRheumatology and Clinical Immunology Unit, ASST Spedali Civili and University of Brescia, Brescia, Italy.
Victoria BitsadzeDepartment of Obstetrics and Gynecology, I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University), Moscow, Russia.
Jamilya KhizroevaDepartment of Obstetrics and Gynecology, I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University), Moscow, Russia.
Sonia ZattiObstetric and Gynecology Unit, ASST Spedali Civili of Brescia, Brescia, Italy.
Laura AndreoliRheumatology and Clinical Immunology Unit, ASST Spedali Civili and University of Brescia, Brescia, Italy.
Elisa FazziChild Neurology and Psychiatry Unit, Department of Clinical and Experimental Sciences, ASST Spedali Civili and University of Brescia, Brescia, Italy.
Franco FranceschiniRheumatology and Clinical Immunology Unit, ASST Spedali Civili and University of Brescia, Brescia, Italy.
Alexander MakatsariyaDepartment of Obstetrics and Gynecology, I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University), Moscow, Russia.
Yehuda ShoenfeldDepartment of Medicine 'B', The Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Ramat Gan, Israel.
Angela TincaniRheumatology and Clinical Immunology Unit, ASST Spedali Civili and University of Brescia, Brescia, Italy.
University of Brescia · ITSechenov University · RUAzienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia · ITTel Aviv University · IL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The management of reproductive issues in women with inflammatory arthritis has greatly changed over decades. In the 1980-1990s, women with refractory forms of arthritis were either not able to get pregnant or did choose not to get pregnant because of their disabling disease. Hence, the traditional belief that pregnancy can induce a remission of arthritis. The availability of biologic agents has allowed a good control of aggressive forms of arthritis. The main topic of discussion during preconception counselling is the use of drugs during pregnancy and breastfeeding. Physicians are now supported by international recommendations released by the European League Against Rheumatism and the American College of Rheumatology, but still they must face with cultural reluctance in accepting that a pregnant woman can take medications. Patient-physician communication should be centered on the message that active maternal disease during pregnancy is detrimental to fetal health. Keeping maternal disease under control with drugs which are not harmful to the fetus is the best way to ensure the best possible outcome for both the mother and the baby. However, there might be concerns about the influence of the

Indexed as

children’s developmentimmunosuppressantspregnancypsoriatic arthritisrheumatoid arthritisspondyloarthritis

Identifiers

PMID33815108
PMCPMC8013697
OpenAlexW3137760338

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.