Evidence map›Paper›PMID 33815062›Full record

ArticleFrontiers in cellular neuroscience2021

Endocannabinoids and Dopamine Balance Basal Ganglia Output.

Lilach Gorodetski, Yocheved Loewenstern, Anna Faynveitz, Izhar Bar-Gad, Kim T Blackwell, Alon Korngreen

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cellular neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Lilach GorodetskiThe Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat Gan, Israel.
Yocheved LoewensternThe Leslie and Susan Gonda Interdisciplinary Brain Research Center, Bar-Ilan University, Ramat Gan, Israel.
Anna FaynveitzThe Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat Gan, Israel.
Izhar Bar-GadThe Leslie and Susan Gonda Interdisciplinary Brain Research Center, Bar-Ilan University, Ramat Gan, Israel.
Kim T BlackwellDepartment of Bioengineering, George Mason University, Fairfax, VA, United States.
Alon KorngreenThe Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat Gan, Israel.
Bar-Ilan University · ILGeorge Mason University · US

Funding

CRCNS: Spatio-temporal Dynamics of Dopamine Activated 2nd Messenger PathwaysR01AA016022 · NIAAA · GEORGE MASON UNIVERSITY · PI BLACKWELL, KIM L, LOVINGER, DAVID · 2005 to 2017
$2.6M
mTOR, a new target for opioid-induced tolerance and hyperalgesiaR01DA033390 · NIDA · RBHS-NEW JERSEY MEDICAL SCHOOL · PI TAO, YUAN-XIANG · 2013 to 2017
$1.8M
CRCNS: US-French Collaboration: Dopamine modulation of calcium in STDPR01DA038890 · NIDA · GEORGE MASON UNIVERSITY · PI BLACKWELL, KIM L · 2014 to 2017
$637k
NIAAA NIH HHS R01 AA016022NIDA NIH HHS R01 DA033390NIDA NIH HHS R01 DA038890
6 · The paper itself

Abstract

The entopeduncular nucleus is one of the basal ganglia's output nuclei, thereby controlling basal ganglia information processing. Entopeduncular nucleus neurons integrate GABAergic inputs from the Striatum and the globus pallidus, together with glutamatergic inputs from the subthalamic nucleus. We show that endocannabinoids and dopamine interact to modulate the long-term plasticity of all these primary afferents to the entopeduncular nucleus. Our results suggest that the interplay between dopamine and endocannabinoids determines the balance between direct pathway (striatum) and indirect pathway (globus pallidus) in entopeduncular nucleus output. Furthermore, we demonstrate that, despite the lack of axon collaterals, information is transferred between neighboring neurons in the entopeduncular nucleus

Indexed as

basal gangliadopamineendocannabinoidsentopeduncular nucleuslong-term plasticity

Identifiers

PMID33815062
PMCPMC8010132
OpenAlexW3136428013

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.