ArticleFrontiers in neuroscience2021
Scopolamine Impairs Spatial Information Recorded With "Miniscope" Calcium Imaging in Hippocampal Place Cells.
Article in Frontiers in neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 21 citations in OpenAlex.
- Large-Scale Neural Recording Technologies for Investigating Circuit Dysfunction and Functional Biomarker Discovery in Animal Models of Alzheimer's Disease.International journal of molecular sciences · 2026Review
- Hippocampal criticality tracks cognitive demand and shifts with memory impairment.Communications biology · 2026Article
- Murine Non-Transgenic Models of Alzheimer's Disease Pathology: Focus on Risk Factors.Brain sciences · 2025Review
- From microelectrode arrays to all-optical and multimodal neural interfaces: emerging platforms for spatiotemporal interrogation ofFrontiers in synaptic neuroscience · 2025Review
- Calcium Signalling in Neurological Disorders, with Insights from Miniature Fluorescence Microscopy.Cells · 2024Review
- Dynamic changes in the hippocampal neuronal circuits activity following acute stress revealed by miniature fluorescence microscopy imaging.Molecular brain · 2024Article
- Protocol for calcium imaging and analysis of hippocampal CA1 activity evoked by non-spatial stimuli.STAR protocols · 2024Article
- Hippocampal cognitive and relational map paradigms explored by multisensory encoding recording with wide-field calcium imaging.iScience · 2024Article
- Septo-hippocampal dynamics and the encoding of space and time.Trends in neurosciences · 2023Review
- Article
- Editorial: Updates on memory modulation in health and disease.Frontiers in behavioral neuroscience · 2023Article
- Astrocytes Reduce Store-Operated CaPharmaceuticals (Basel, Switzerland) · 2022Article
- Neural basis of topographical disorientation in the primate posterior cingulate gyrus based on a labeled graph.AIMS neuroscience · 2022Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The hippocampus and associated cholinergic inputs have important roles in spatial memory in rodents. Muscarinic acetylcholine receptors (mAChRs) are involved in the communication of cholinergic signals and regulate spatial memory. They have been found to impact the memory encoding process, but the effect on memory retrieval is controversial. Previous studies report that scopolamine (a non-selective antagonist of mAChR) induces cognitive deficits on animals, resulting in impaired memory encoding, but the effect on memory retrieval is less certain. We tested the effects of blocking mAChRs on hippocampal network activity and neural ensembles that had previously encoded spatial information. The activity of hundreds of neurons in mouse hippocampal CA1 was recorded using calcium imaging with a miniaturised fluorescent microscope and properties of place cells and neuronal ensemble behaviour in a linear track environment were observed. We found that the decoding accuracy and the stability of spatial representation revealed by hippocampal neural ensemble were significantly reduced after the administration of scopolamine. Several other parameters, including neural firing rate, total number of active neurons, place cell number and spatial information content were affected. Similar results were also observed in a simulated hippocampal network model. This study enhances the understanding of the function of mAChRs on spatial memory impairment.
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