ReviewFrontiers in neuroscience2021
Beginning to See the Light: Lessons Learned From the Development of the Circadian System for Optimizing Light Conditions in the Neonatal Intensive Care Unit.
Review in Frontiers in neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 4 syntheses or guidelines pooled it, 38 citations in OpenAlex.
- Challenges and Recommendations for Integrating Circadian Medicine in Critical Care: A Roadmap.Chest · 2026Guideline
- Cycled light in the intensive care unit for preterm and low birth weight infants.The Cochrane database of systematic reviews · 2024Pooled it
- Nursing Interventions That Promote Sleep in Preterm Newborns in the Neonatal Intensive Care Units: An Integrative Review.International journal of environmental research and public health · 2022Pooled it
- Effectiveness of combined versus single circadian interventions in neonatal and pediatric intensive care units: a systematic review with meta-analysis.Frontiers in neurologyPooled it
- Towards implementation of continuous biologically relevant light measurements at the bedside in the Neonatal Intensive Care Unit.Npj biological timing and sleep · 2026Article
- Supporting Parental Decision-Making After Life-Limiting Fetal Diagnoses: The Role of Perinatal Hospice and the NOVA-L Decision Support System.Healthcare (Basel, Switzerland) · 2026Article
- The impact of sleep in high-risk infants.Pediatric research · 2025Review
- Article
- Circadian Rhythms, Immune Regulation, and the Risk for Sepsis: Circadian Rhythms and Neonatal Care.Clinics in perinatology · 2025Review
- The role of light exposure in infant circadian rhythm establishment: A scoping review perspective.European journal of pediatrics · 2024Article
- Vestibular stimulation for promoting development and preventing morbidity in preterm infants.The Cochrane database of systematic reviews · 2024Article
- Best evidence summary of sleep protection in premature infants in the neonatal intensive care unit: a narrative review.Translational pediatrics · 2024Review
- Biologically aware lighting for newborn intensive care.Journal of perinatology : official journal of the California Perinatal Association · 2023Article
- Article
- Designing artificial circadian environments with multisensory cares for supporting preterm infants' growth in NICUs.Frontiers in neuroscience · 2023Review
- Characterizing light-dark cycles in the Neonatal Intensive Care Unit: a retrospective observational study.Frontiers in physiology · 2023Article
- Effects of the neonatal intensive care environment on circadian health and development of preterm infants.Frontiers in physiology · 2023Review
- Unobtrusive cot side sleep stage classification in preterm infants using ultra-wideband radar.Frontiers in sleep · 2023Article
- Evaluation of tissue perfusion status in moderate to late preterm.Physiological research · 2022Article
- Breast Milk and the Importance of Chrononutrition.Frontiers in nutrition · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The circadian timing system optimizes health by temporally coordinating behavior and physiology. During mammalian gestation, fetal circadian rhythms are synchronized by the daily fluctuations in maternal body temperature, hormones and nutrients. Circadian disruption during pregnancy is associated with negative effects on developmental outcomes in the offspring, highlighting the importance of regular and robust 24-h rhythms over gestation. In the case of preterm birth (before 37 weeks of gestation), maternal cues no longer synchronize the neonate's circadian system, which may adversely affect the neonate. There is increasing evidence that introducing robust light-dark cycles in the Neonatal Intensive Care Unit has beneficial effects on clinical outcomes in preterm infants, such as weight gain and hospitalization time, compared to infants exposed to constant light or constant near-darkness. However, the biological basis for these effects and the relationship with the functional and anatomical development of the circadian system is not fully understood. In this review, we provide a concise overview of the effects of light-dark cycles on clinical outcomes of preterm neonates in the NICU and its alignment with the development of the circadian system.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.