ArticleMacromolecules2019
PET-RAFT and SAXS: High Throughput Tools to Study Compactness and Flexibility of Single-Chain Polymer Nanoparticles.
Article in Macromolecules, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Self-driving lab for the data-driven design of single-chain polymer nanoparticles.Cell press blue · 2026Article
- Seeking Precise Protein-like Functions from Random Heteropolymer Ensemble and through Dimensionality Reduction.ACS central science · 2025Review
- Enhanced Diffusion and Retention of Proteoglycan Replacements in Cartilage through Thermoresponsive Polyelectrolytes.Macromolecules · 2025Article
- Kinetics and Retention of Polystyrenesulfonate for Proteoglycan Replacement in Cartilage.Biomacromolecules · 2024Article
- Malleable, Ultrastrong Antibacterial Thermosets Enabled by Guanidine Urea Structure.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Navigating the Expansive Landscapes of Soft Materials: A User Guide for High-Throughput Workflows.ACS polymers Au · 2023Review
- Applied machine learning as a driver for polymeric biomaterials design.Nature communications · 2023Review
- The Nanostructured Self-Assembly and Thermoresponsiveness in Water of Amphiphilic Copolymers Carrying Oligoethylene Glycol and Polysiloxane Side Chains.Pharmaceutics · 2023Article
- A User's Guide to Machine Learning for Polymeric Biomaterials.ACS polymers Au · 2023Review
- Examining polymer-protein biophysical interactions with small-angle x-ray scattering and quartz crystal microbalance with dissipation.Journal of biomedical materials research. Part A · 2023Article
- A fully automated platform for photoinitiated RAFT polymerization.Digital discovery · 2023Article
- When does a macromolecule transition from a polymer chain to a nanoparticle?Nanoscale advances · 2022Article
- Machine-Assisted Discovery of Chondroitinase ABC Complexes toward Sustained Neural Regeneration.Advanced healthcare materials · 2022Article
- Data-Driven Methods for Accelerating Polymer Design.ACS polymers Au · 2022Review
- Origin of Proteolytic Stability of Peptide-Brush Polymers as Globular Proteomimetics.ACS central science · 2021Article
- Where Biology and Traditional Polymers Meet: The Potential of Associating Sequence-Defined Polymers for Materials Science.JACS Au · 2021Review
- Bias free multiobjective active learning for materials design and discovery.Nature communications · 2021Article
- Automation and data-driven design of polymer therapeutics.Advanced drug delivery reviews · 2021Review
- Automated PET-RAFT Polymerization Towards Pharmaceutical Amorphous Solid Dispersion Development.ACS applied polymer materials · 2021Article
- Advances in the Multi-Orthogonal Folding of Single Polymer Chains into Single-Chain Nanoparticles.Polymers · 2021Review
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
From protein science, it is well understood that ordered folding and 3D structure mainly arises from balanced and noncovalent polar and nonpolar interactions, such as hydrogen bonding. Similarly, it is understood that single-chain polymer nanoparticles (SCNPs) will also compact and become more rigid with greater hydrophobicity and intrachain hydrogen bonding. Here, we couple high throughput photoinduced electron/energy transfer reversible addition-fragmentation chain-transfer (PET-RAFT) polymerization with high throughput small-angle X-ray scattering (SAXS) to characterize a large combinatorial library (>450) of several homopolymers, random heteropolymers, block copolymers, PEG-conjugated polymers, and other polymer-functionalized polymers. Coupling these two high throughput tools enables us to study the major influence(s) for compactness and flexibility in higher breadth than ever before possible. Not surprisingly, we found that many were either highly disordered in solution, in the case of a highly hydrophilic polymer, or insoluble if too hydrophobic. Remarkably, we also found a small group (9/457) of PEG-functionalized random heteropolymers and block copolymers that exhibited compactness and flexibility similar to that of bovine serum albumin (BSA) by dynamic light scattering (DLS), NMR, and SAXS. In general, we found that describing a rough association between compactness and flexibility parameters (
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.