ArticleJournal of chemical education2020
DNA nanotechnology in the undergraduate laboratory: Analysis of molecular topology using DNA nanoswitches.
Article in Journal of chemical education, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed.
- DNA Nanotechnology in the Undergraduate Laboratory: Isothermal Assembly and Quantification of DNA Nanostructures.JACS Au · 2026Article
- [Binary encryption comprehensive experiment based on agarose gel electrophoresis].Se pu = Chinese journal of chromatography · 2026Article
- DNA Nanotechnology in the Undergraduate Laboratory: Toehold-Less Strand Displacement in Switchback DNA.JACS Au · 2025Article
- Transitioning undergraduate research from wet lab to the virtual in the wake of a pandemic.Biochemistry and molecular biology education : a bimonthly publication of the International Union of Biochemistry and Molecular Biology · 2020Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
There is a disconnect between the cutting-edge research done in academic labs, such as nanotechnology, and what is taught in undergraduate labs. In the current undergraduate curriculum, very few students get a chance to do hands-on experiments in nanotechnology-related experiments most of which are through selective undergraduate research programs. In most cases, complicated synthesis procedures, expensive reagents, and requirement of specific instrumentation prevent broad adaptation of nanotechnology-based experiments to laboratory courses. DNA, being a nanoscale molecule, has recently been used in bottom-up nanotechnology with applications in sensing, nano-robotics, and computing. In this article, we propose a simple experiment involving the synthesis of a DNA nanoswitch that can change its shape from a linear "off" state to a looped "on" state in the presence of a target DNA molecule. The experiment also demonstrates the programmable topology of the looped state of the nanoswitch and its effect on gel migration. The experiment is easy to adapt in an undergraduate laboratory, requires only agarose gel electrophoresis, a minimal set-up cost for materials, and can be completed in a 3-hour time frame.
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Registered trials
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