Evidence map›Paper›PMID 33814491›Full record

ReviewInternal medicine (Tokyo, Japan)2021

Self-remitting Elevation of Adenosine Deaminase Levels in the Cerebrospinal Fluid with Autoimmune Glial Fibrillary Acidic Protein Astrocytopathy: A Case Report and Review of the Literature.

Sota Nakamura, Teppei Fujioka, Shoji Kawashima, Takatsune Kawaguchi, Masayuki Mizuno, Masahiro Omura, Kenji Okita, Akio Kimura, Takayoshi Shimohata, Noriyuki Matsukawa

Open access · diamondAbstract readCase ReportsReview
In one paragraph

Review in Internal medicine (Tokyo, Japan), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.7field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Sota NakamuraDepartment of Neurology, Nagoya City University Graduate School of Medical Sciences, Japan.
Teppei FujiokaDepartment of Neurology, Nagoya City University Graduate School of Medical Sciences, Japan.
Shoji KawashimaDepartment of Neurology, Nagoya City University Graduate School of Medical Sciences, Japan.
Takatsune KawaguchiDepartment of Radiology, Nagoya City University Graduate School of Medical Sciences, Japan.
Masayuki MizunoDepartment of Neurology, Nagoya City University Graduate School of Medical Sciences, Japan.
Masahiro OmuraDepartment of Neurology, Nagoya City University Graduate School of Medical Sciences, Japan.
Kenji OkitaDepartment of Neurology, Nagoya City University Graduate School of Medical Sciences, Japan.
Akio KimuraDepartment of Neurology, Gifu University Graduate School of Medicine, Japan.
Takayoshi ShimohataDepartment of Neurology, Gifu University Graduate School of Medicine, Japan.
Noriyuki MatsukawaDepartment of Neurology, Nagoya City University Graduate School of Medical Sciences, Japan.
Nagoya City University · JPGifu University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A 29-year-old man presented with a high-grade fever, headache, and urinary retention, in addition to meningeal irritation and myoclonus in his upper extremities. A cerebrospinal fluid (CSF) examination showed pleocytosis and high adenosine deaminase (ADA) levels with no evidence of bacterial infection, including Mycobacterium tuberculosis. T2-weighted brain magnetic resonance imaging showed transient hyper-intensity lesions at the splenium of the corpus callosum (SCC), bilateral putamen, and pons during the course of the disease. The CSF was positive for anti-glial fibrillary acidic protein (GFAP) antibodies. He was diagnosed with autoimmune GFAP astrocytopathy. The present case shows that the combination of an elevated ADA level in the CSF and reversible T2-weighted hyper-intensity on the SCC supports the diagnosis of autoimmune GFAP encephalopathy.

Indexed as

Adenosine DeaminaseEncephalitisAdultAstrocytesAutoantibodiesGlial Fibrillary Acidic ProteinHumansMaleAdenosine DeaminaseAutoantibodiesGlial Fibrillary Acidic Proteinadenosine deaminase (ADA)autoimmune GFAP astrocytopathyglial fibrillary acidic protein (GFAP)myoclonusreversible splenial lesionurinary retention

Identifiers

PMID33814491
PMCPMC8502650
OpenAlexW3152220996

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.